RT Journal Article
T1 Clinical characteristics and outcome of bacteraemia caused by Enterobacter cloacae and Klebsiella aerogenes: more similarities than differences
A1 Álvarez-Marín, Rocío
A1 Lepe, José Antonio
A1 Gasch-Blasi, Oriol
A1 Rodríguez-Martínez, José Manuel
A1 Calvo-Montes, Jorge
A1 Lara-Contreras, Rosario
A1 Martín-Gandul, Cecilia
A1 Tubau-Quintano, Fe
A1 Cano-García, María Eliecer
A1 Rodríguez-López, Fernando
A1 Rodríguez-Baño, Jesús
A1 Pujol-Rojo, Miquel
A1 Torre-Cisneros, Julián
A1 Martínez-Martínez, Luis
A1 Pascual-Hernández, Álvaro
A1 Jiménez-Mejías, Manuel E.
K1 Enterobacter cloacae
K1 Klebsiella aerogenes
K1 Enterobacter aerogenes
K1 Bacteraemia
K1 Bacteriemia
K1 Quinolone resistance mechanism
K1 Case–control study
K1 Estudios de casos y controles
AB Objectives: The genus Enterobacter is a common cause of nosocomial infections. Historically, the most frequent Enterobacter species were those of Enterobacter cloacae complex and Enterobacter aerogenes. In 2019, E. aerogenes was re-classified as Klebsiella aerogenes owing to its higher genotypic similarity with the genus Klebsiella. Our objective was to characterise and compare the clinical profiles of bacteraemia caused by E. cloacae and K. aerogenes.Methods: This 3-year multicentre, prospective cohort study enrolled consecutive patients with bacteraemia by E. cloacae or K. aerogenes. Baseline characteristics, bacteraemia features (source, severity, treatment), antibiotic susceptibility, resistance mechanisms and mortality were analysed.Results: The study included 285 patients with bacteraemia [196 (68.8%) E. cloacae and 89 (31.2%) K. aerogenes]. The groups showed no differences in age, sex, previous use of invasive devices, place of acquisition, sources or severity at onset. The Charlson score was higher among patients with E. cloacae bacteraemia [2 (1-4) vs. 1 (0.5-3); P = 0.018], and previous antibiotic therapy was more common in patients with K. aerogenes bacteraemia (57.3% vs. 41.3%; P = 0.01). Mortality was 19.4% for E. cloacae and 20.2% for K. aerogenes (P = 0.869). Antibiotic susceptibility was similar for both species, and the incidence of multidrug resistance or ESBL production was low (6% and 5.3%, respectively), with no differences between species.Conclusion: Bacteraemias caused by E. cloacae and K. aerogenes share similar patient profiles, presentation and prognosis. Patients with E. cloacae bacteraemia had more co-morbidities and those with K. aerogenes bacteraemia had received more antibiotics.
PB Elsevier
SN 2213-7165
YR 2021
FD 2021-05-06
LK http://hdl.handle.net/10668/3583
UL http://hdl.handle.net/10668/3583
LA en
NO Álvarez-Marín R, Lepe JA, Gasch-Blasi O, Rodríguez-Martínez JM, Calvo-Montes J, Lara-Contreras R, et al. Clinical characteristics and outcome of bacteraemia caused by Enterobacter cloacae and Klebsiella aerogenes: more similarities than differences. J Glob Antimicrob Resist. 2021 Jun;25:351-358
DS RISalud
RD Apr 9, 2025