RT Generic
T1 Escherichia coli: an old friend with new tidings
A1 Vila, J.
A1 Saez-Lopez, E.
A1 Johnson, J. R.
A1 Romling, U.
A1 Dobrindt, U.
A1 Canton, R.
A1 Giske, C. G.
A1 Naas, T.
A1 Carattoli, A.
A1 Martinez-Medina, M.
A1 Bosch, J.
A1 Retamar, P.
A1 Rodriguez-Bano, J.
A1 Baquero, F.
A1 Soto, S. M.
K1 Escherichia coli
K1 pathogenesis
K1 antimicrobial resistance
K1 clinical
K1 epidemiology
K1 evolution
K1 Spectrum-beta-lactamase
K1 Cyclic-di-gmp
K1 Onset neonatal sepsis
K1 Blood-stream infections
K1 Invasive e. coli
K1 Carbapenemase-producing enterobacteriaceae
K1 Comparative genomic analysis
K1 Gram-negative organisms
K1 In-vitro activity
K1 Klebsiella-pneumoniae
AB Escherichia coli is one of the most-studied microorganisms worldwide but its characteristics are continually changing. Extraintestinal E. coli infections, such as urinary tract infections and neonatal sepsis, represent a huge public health problem. They are caused mainly by specialized extraintestinal pathogenic E. coli (ExPEC) strains that can innocuously colonize human hosts but can also cause disease upon entering a normally sterile body site. The virulence capability of such strains is determined by a combination of distinctive accessory traits, called virulence factors, in conjunction with their distinctive phylogenetic background. It is conceivable that by developing interventions against the most successful ExPEC lineages or their key virulence/colonization factors the associated burden of disease and health care costs could foreseeably be reduced in the future. On the other hand, one important problem worldwide is the increase of antimicrobial resistance shown by bacteria. As underscored in the last WHO global report, within a wide range of infectious agents including E. coli, antimicrobial resistance has reached an extremely worrisome situation that 'threatens the achievements of modern medicine'. In the present review, an update of the knowledge about the pathogenicity, antimicrobial resistance and clinical aspects of this 'old friend' was presented.New knowledgements about pathogenesis, antimicrobial resistance and clinical aspects of Escherichia coli.New knowledgements about pathogenesis, antimicrobial resistance and clinical aspects of Escherichia coli.
PB Oxford univ press
SN 0168-6445
YR 2016
FD 2016-07-01
LK http://hdl.handle.net/10668/18952
UL http://hdl.handle.net/10668/18952
LA en
DS RISalud
RD Apr 18, 2025