%0 Journal Article
%A Molina, Noemi
%A González, Ana
%A Monopoli, Donato
%A Mentado, Belinda
%A Becerra, José
%A Santos-Ruiz, Leonor
%A Vida, Yolanda
%A Perez-Inestrosa, Ezequiel
%T Dendritic Scaffold onto Titanium Implants. A Versatile Strategy Increasing Biocompatibility
%D 2020
%U http://hdl.handle.net/10668/3530
%X Osseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally been solved by coating the former with "organic" ceramics, such as hydroxyapatite. A novel approach is hereby presented, immobilizing covalently dendrimeric structures onto titanium implants. Amide-based amino terminal dendrons were synthetized and coupled to titanium surfaces in a versatile and controlled way. The dendritic moieties provide an excellent scaffold for the covalent immobilization of bioactive molecules, such as extracellular matrix (ECM) protein components or antibiotics. Herein, tripeptide arginine-glycine-aspartic acid (RGD) motifs were used to decorate the dendritic scaffolds and their influence on cell adhesion and proliferation processes was evaluated.
%K Dendritic structures
%K Titanium implants
%K Tripeptide arginine-glycine-aspartic acid (RGD) recognition pattern
%K Materials testing
%K Cell adhesion
%K Titanio
%K Oseointegración
%K Prótesis e implantes
%K Ensayo de materiales
%K Adhesión celular
%K Dendrímeros
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