RT Journal Article
T1 Obesity as a Risk Factor for Prostate Cancer Mortality: A Systematic Review and Dose-Response Meta-Analysis of 280,199 Patients
A1 Rivera-Izquierdo, Mario
A1 Pérez de Rojas, Javier
A1 Martínez-Ruiz, Virginia
A1 Pérez-Gómez, Beatriz
A1 Sanchez-Perez, Maria-Jose
A1 Khan, Khalid Saeed
A1 Jiménez-Moleón, José Juan
K1 Body mass index
K1 Prostate cancer specific mortality
K1 All-cause mortality
K1 Outcomes
K1 Causation
K1 Índice de masa corporal
K1 Neoplasias de la próstata
K1 Mortalidad
K1 Resultado del tratamiento
K1 Causalidad
K1 Revisión sistemática
K1 Metaanálisis
AB The aim of this study was to systematically review all evidence evaluating obesity as a prognostic factor for PC mortality. Cohort and case-control studies reporting mortality among PC patients stratified by body mass index (BMI) were included. The risk of mortality among obese patients (BMI ≥ 30) was compared with the risk for normal weight (BMI < 25) patients, pooling individual hazard ratios (HR) in random-effects meta-analyses. Reasons for heterogeneity were assessed in subgroup analyses. Dose-response associations for BMI per 5 kg/m2 change were assessed. Among 7278 citations, 59 studies (280,199 patients) met inclusion criteria. Obesity was associated with increased PC-specific mortality (HR: 1.19, 95% CI: 1.10-1.28, I2: 44.4%) and all-cause mortality (HR: 1.09, 95% CI: 1.00-1.18, I2: 43.9%). There was a 9% increase (95% CI: 5-12%, I2: 39.4%) in PC-specific mortality and 3% increase (95% CI: 1-5%, I2: 24.3%) in all-cause mortality per 5 kg/m2 increase in BMI. In analyses restricted to the higher quality subgroup (NOS ≥ 8), obesity was associated with increased PC-specific mortality (HR: 1.24, 95% CI: 1.14-1.35, I2: 0.0%) and maintained the dose-response relationship (HR: 1.11 per 5 kg/m2 increase in BMI, 95% CI: 1.07-1.15, I2: 26.6%). Obesity had a moderate, consistent, temporal, and dose-response association with PC mortality. Weight control programs may have a role in improving PC survival.
PB MDPI
YR 2021
FD 2021-08-19
LK http://hdl.handle.net/10668/4195
UL http://hdl.handle.net/10668/4195
LA en
NO Rivera-Izquierdo M, Pérez de Rojas J, Martínez-Ruiz V, Pérez-Gómez B, Sánchez MJ, Khan KS, et al. Obesity as a Risk Factor for Prostate Cancer Mortality: A Systematic Review and Dose-Response Meta-Analysis of 280,199 Patients. Cancers. 2021 Aug 19;13(16):4169
DS RISalud
RD Apr 7, 2025