RT Journal Article
T1 Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia.
A1 Andreu-Bernabeu, Álvaro
A1 Díaz-Caneja, Covadonga M
A1 Costas, Javier
A1 De Hoyos, Lucía
A1 Stella, Carol
A1 Gurriarán, Xaquín
A1 Alloza, Clara
A1 Fañanás, Lourdes
A1 Bobes, Julio
A1 González-Pinto, Ana
A1 Crespo-Facorro, Benedicto
A1 Martorell, Lourdes
A1 Vilella, Elisabet
A1 Muntané, Gerard
A1 Nacher, Juan
A1 Molto, María Dolores
A1 Aguilar, Eduardo Jesús
A1 Parellada, Mara
A1 Arango, Celso
A1 González-Peñas, Javier
AB Previous research suggests an association of loneliness and social isolation (LNL-ISO) with schizophrenia. Here, we demonstrate a LNL-ISO polygenic score contribution to schizophrenia risk in an independent case-control sample (N = 3,488). We then subset schizophrenia predisposing variation based on its effect on LNL-ISO. We find that genetic variation with concordant effects in both phenotypes shows significant SNP-based heritability enrichment, higher polygenic contribution in females, and positive covariance with mental disorders such as depression, anxiety, attention-deficit hyperactivity disorder, alcohol dependence, and autism. Conversely, genetic variation with discordant effects only contributes to schizophrenia risk in males and is negatively correlated with those disorders. Mendelian randomization analyses demonstrate a plausible bi-directional causal relationship between LNL-ISO and schizophrenia, with a greater effect of LNL-ISO liability on schizophrenia than vice versa. These results illustrate the genetic footprint of LNL-ISO on schizophrenia.
YR 2022
FD 2022-01-10
LK http://hdl.handle.net/10668/19535
UL http://hdl.handle.net/10668/19535
LA en
DS RISalud
RD Apr 12, 2025