RT Journal Article
T1 Fiber intake modulates the association of alcohol intake with breast cancer.
A1 Romieu, Isabelle
A1 Ferrari, Pietro
A1 Chajès, Veronique
A1 de Batlle, Jordi
A1 Biessy, Carine
A1 Scoccianti, Chiara
A1 Dossus, Laure
A1 Christine Boutron, Marie
A1 Bastide, Nadia
A1 Overvad, Kim
A1 Olsen, Anja
A1 Tjønneland, Anne
A1 Kaaks, Rudolf
A1 Boeing, Heiner
A1 Trichopoulou, Antonia
A1 Lagiou, Pagona
A1 Trichopoulos, Dimitrios
A1 Palli, Domenico
A1 Sieri, Sabina
A1 Tumino, Rosario
A1 Vineis, Paolo
A1 Panico, Salvatore
A1 Bueno-de-Mesquita, H B As
A1 Gils, Carla H
A1 Peeters, Petra H
A1 Lund, Eiliv
A1 Skeie, Guri
A1 Weiderpass, Elisabete
A1 Ramón Quirós, J
A1 Chirlaque, María-Dolores
A1 Ardanaz, Eva
A1 Sanchez-Perez, Maria-Jose
A1 Duell, Eric J
A1 Amiano Etxezarreta, Pilar
A1 Borgquist, Signe
A1 Hallmans, Göran
A1 Johansson, Ingegerd
A1 Maria Nilsson, Lena
A1 Khaw, Kay-Tee
A1 Wareham, Nick
A1 Key, Timothy J
A1 Travis, Ruth C
A1 Murphy, Neil
A1 Wark, Petra A
A1 Riboli, Elio
K1 alcohol
K1 breast cancer
K1 epidemiology
K1 nutrition
AB Alcohol intake has been related to an increased risk of breast cancer (BC) while dietary fiber intake has been inversely associated to BC risk. A beneficial effect of fibers on ethanol carcinogenesis through their impact on estrogen levels is still controversial. We investigated the role of dietary fiber as a modifying factor of the association of alcohol and BC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 334,850 women aged 35-70 years at baseline enrolled in the ten countries of the EPIC study and followed up for 11.0 years on average. Information on fiber and alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. Hazard ratios (HR) of developing invasive BC according to different levels of alcohol and fiber intake were computed. During 3,670,439 person-years, 11,576 incident BC cases were diagnosed. For subjects with low intake of fiber (24.2 g/day) the risk of BC was 1.02 (0.99-1.05) (test for interaction p = 0.011). This modulating effect was stronger for fiber from vegetables. Our results suggest that fiber intake may modulate the positive association of alcohol intake and BC. Alcohol is well known to increase the risk for BC, while a fiber-rich diet has the opposite effect. Here the authors find a significant interaction between both lifestyle factors indicating that high fiber intake can ease the adverse effects associated with alcohol consumption. Consequently, women with high alcohol intake and low fiber intake (
YR 2017
FD 2017
LK http://hdl.handle.net/10668/10421
UL http://hdl.handle.net/10668/10421
LA en
DS RISalud
RD Apr 6, 2025