RT Journal Article
T1 Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort.
A1 Obón-Santacana, Mireia
A1 Lujan-Barroso, Leila
A1 Freisling, Heinz
A1 Cadeau, Claire
A1 Fagherazzi, Guy
A1 Boutron-Ruault, Marie-Christine
A1 Kaaks, Rudolf
A1 Fortner, Renée T
A1 Boeing, Heiner
A1 Ramón Quirós, J
A1 Molina-Montes, Esther
A1 Chamosa, Saioa
A1 Castaño, José María Huerta
A1 Ardanaz, Eva
A1 Khaw, Kay-Tee
A1 Wareham, Nick
A1 Key, Tim
A1 Trichopoulou, Antonia
A1 Lagiou, Pagona
A1 Naska, Androniki
A1 Palli, Domenico
A1 Grioni, Sara
A1 Tumino, Rosario
A1 Vineis, Paolo
A1 De Magistris, Maria Santucci
A1 Bueno-de-Mesquita, H B
A1 Peeters, Petra H
A1 Wennberg, Maria
A1 Bergdahl, Ingvar A
A1 Vesper, Hubert
A1 Riboli, Elio
A1 Duell, Eric J
K1 Acrylamide
K1 Biomarkers
K1 Diet
K1 Glycidamide
K1 Hemoglobin adducts
K1 Nutrition
AB Acrylamide was classified as 'probably carcinogenic' to humans in 1994 by the International Agency for Research on Cancer. In 2002, public health concern increased when acrylamide was identified in starchy, plant-based foods, processed at high temperatures. The purpose of this study was to identify which food groups and lifestyle variables were determinants of hemoglobin adduct concentrations of acrylamide (HbAA) and glycidamide (HbGA) in 801 non-smoking postmenopausal women from eight countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Biomarkers of internal exposure were measured in red blood cells (collected at baseline) by high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS) . In this cross-sectional analysis, four dependent variables were evaluated: HbAA, HbGA, sum of total adducts (HbAA + HbGA), and their ratio (HbGA/HbAA). Simple and multiple regression analyses were used to identify determinants of the four outcome variables. All dependent variables (except HbGA/HbAA) and all independent variables were log-transformed (log2) to improve normality. Median (25th-75th percentile) HbAA and HbGA adduct levels were 41.3 (32.8-53.1) pmol/g Hb and 34.2 (25.4-46.9) pmol/g Hb, respectively. The main food group determinants of HbAA, HbGA, and HbAA + HbGA were biscuits, crackers, and dry cakes. Alcohol intake and body mass index were identified as the principal determinants of HbGA/HbAA. The total percent variation in HbAA, HbGA, HbAA + HbGA, and HbGA/HbAA explained in this study was 30, 26, 29, and 13 %, respectively. Dietary and lifestyle factors explain a moderate proportion of acrylamide adduct variation in non-smoking postmenopausal women from the EPIC cohort.
YR 2016
FD 2016-02-05
LK http://hdl.handle.net/10668/9815
UL http://hdl.handle.net/10668/9815
LA en
DS RISalud
RD Apr 11, 2025