RT Journal Article
T1 Acetylcholinesterase inhibitors and healing of hip fracture in Alzheimer's disease patients: a retrospective cohort study.
A1 Eimar, H.
A1 Perez Lara, A.
A1 Tamimi, I.
A1 Márquez Sánchez, P.
A1 Gormaz Talavera, I.
A1 Rojas Tomba, F.
A1 García de la Oliva, T.
A1 Tamimi, F.
K1 Fracture Healing
K1 Bone
K1 Acetylcholine
K1 Acetylcholinesterasa Inhibitors
K1 Parasympathetic Nervous System
K1 Enfermedad de Alzheimer
K1 Fracturas de cadera
K1 Estudios retrospectivos
K1 Femenino
K1 Anciano
AB OBJECTIVESThis study was designed to assess effects of cholinergic stimulation using acetylcholinesterase inhibitors (AChEIs), a group of drugs that stimulate cholinergic receptors and are used to treat Alzheimer's disease (AD), on healing of hip fractures.METHODSA retrospective cohort study was performed using 46-female AD patients, aged above 75 years, who sustained hip fractures. Study analyses included the first 6-months after hip fracture fixation procedure. Presence of AChEIs was used as predictor variable. Other variables that could affect study outcomes: age, body mass index (BMI), mental state or type of hip fracture, were also included. Radiographic union at fracture site (Hammer index), bone quality (Singh index) and fracture healing complications were recorded as study outcomes. The collected data was analyzed by student's-t, Mann-Whitney-U and chi-square tests.RESULTSNo significant differences in age, BMI, mental state or type of hip fracture were observed between AChEIs-users and nonusers. However, AChEIs-users had better radiographic union at the fracture site (relative risk (RR),2.7; 95%confidence interval (CI),0.9-7.8), better bone quality (RR,2.0; 95%CI,1.2-3.3) and fewer healing complications (RR,0.8; 95%CI,0.7-1.0) than nonusers.CONCLUSIONIn elderly female patients with AD, the use of AChEIs might be associated with an enhanced fracture healing and minimized complications.
PB International Society of Musculoskeletal and Neuronal Interactions
SN 1108-7161
YR 2013
FD 2013-12
LK http://hdl.handle.net/10668/1551
UL http://hdl.handle.net/10668/1551
LA en
NO Eimar H, Perez Lara A, Tamimi I, Márquez Sánchez P, Gormaz Talavera I, Rojas Tomba F, et al. Acetylcholinesterase inhibitors and healing of hip fracture in Alzheimer's disease patients: a retrospective cohort study. J Musculoskelet Neuronal Interact. 2013; 13(4):454-63
NO Journal Article;
DS RISalud
RD May 9, 2025