RT Journal Article
T1 Circulating metabolomic profile can predict dyslipidemia in HIV patients undergoing antiretroviral therapy.
A1 Rodriguez-Gallego, Esther
A1 Gomez, Josep
A1 Domingo, Pere
A1 Ferrando-Martinez, Sara
A1 Peraire, Joaquim
A1 Vilades, Consuelo
A1 Veloso, Sergi
A1 Lopez-Dupla, Miguel
A1 Beltran-Debon, Raul
A1 Alba, Veronica
A1 Vargas, Montserrat
A1 Castellano, Alfonso J
A1 Leal, Manuel
A1 Pacheco, Yolanda Maria
A1 Ruiz-Mateos, Ezequiel
A1 Gutierrez, Felix
A1 Vidal, Francesc
A1 Rull, Anna
K1 ART therapy
K1 Dyslipidemia
K1 HIV
K1 Lipids
K1 Lipoproteins
K1 Metabolomics
K1 NMR
AB Dyslipidemia in HIV-infected patients is unique and pathophysiologically associated with host factors, HIV itself and the use of antiretroviral therapy (ART). The use of nuclear magnetic resonance spectroscopy (NMR) provides additional data to conventional lipid measurements concerning the number of lipoprotein subclasses and particle sizes. To investigate the ability of lipoprotein profile, we used a circulating metabolomic approach in a cohort of 103 ART-naive HIV-infected patients, who were initiating non-nucleoside analogue transcriptase inhibitor (NNRTI)-based ART, and we subsequently followed up these patients for 36 months. Univariate and multivariate analyses were performed to evaluate the predictive power of NMR spectroscopy. VLDL-metabolism (including VLDL lipid concentrations, sizes, and particle numbers), total triglycerides and lactate levels resulted in good classifiers of dyslipidemia (AUC 0.903). Total particles/HDL-P ratio was significantly higher in ART-associated dyslipidemia compared to ART-normolipidemia (p = 0.001). Large VLDL-Ps were positively associated with both LDL-triglycerides (ρ 0.682, p  Our data suggest that circulating metabolites have better predictive values for HIV/ART-related dyslipidemia onset than do the biochemical markers associated with conventional lipid measurements. NMR identifies changes in VLDL-P, lactate and LDL-TG as potential clinical markers of baseline HIV-dyslipidemia predisposition. Differences in circulating metabolomics, especially differences in particle size, are indicators of important derangements of mitochondrial function that are linked to ART-related dyslipidemia.
YR 2018
FD 2018-04-09
LK http://hdl.handle.net/10668/12377
UL http://hdl.handle.net/10668/12377
LA en
NO Rodríguez-Gallego E, Gómez J, Domingo P, Ferrando-Martínez S, Peraire J, Viladés C, et al. Circulating metabolomic profile can predict dyslipidemia in HIV patients undergoing antiretroviral therapy. Atherosclerosis. 2018 Jun;273:28-36.
DS RISalud
RD Apr 19, 2025