RT Journal Article
T1 PM100117 and PM100118, new antitumor macrolides produced by a marine Streptomyces caniferus GUA-06-05-006A.
A1 Pérez, Marta
A1 Schleissner, Carmen
A1 Fernández, Rogelio
A1 Rodríguez, Pilar
A1 Reyes, Fernando
A1 Zuñiga, Paz
A1 de la Calle, Fernando
A1 Cuevas, Carmen
AB Two new bioactive polyhydroxyl macrolide lactones PM100117 (1) and PM100118 (2) were isolated from the culture broth of the marine-derived Streptomyces caniferus GUA-06-05-006A. Their structures were elucidated by a combination of spectroscopic methods, mainly one-dimensional and 2D NMR and HRESI-MS. They consist of 36-membered macrolides with a side chain containing three deoxy sugars and a 1,4-naphthoquinone chromophore. Compounds 1 and 2 displayed potent cytotoxicity against three human tumor cell lines with GI50 values in the micromolar range, as well as slight antifungal activity against Candida albicans ATCC10231. In addition, both compounds alter the plasma membrane of tumor cells, inducing loss of membrane integrity and subsequent cell permeabilization leading to a fast and dramatic necrotic cell death.
YR 2015
FD 2015-12-09
LK https://hdl.handle.net/10668/24596
UL https://hdl.handle.net/10668/24596
LA en
DS RISalud
RD Apr 5, 2025