RT Journal Article T1 Gender differences in quality of life in adults with long-standing type 1 diabetes mellitus. A1 Castellano-Guerrero, Ana María A1 Guerrero, Raquel A1 Ruiz-Aranda, Desireé A1 Perea, Sofia A1 Pumar, Alfonso A1 Relimpio, Federico A1 Mangas, Miguel Angel A1 Losada, Fernando A1 Martínez-Brocca, Maria Asunción K1 Gender differences K1 Quality of life K1 Type 1 diabetes mellitus AB To assess gender differences in Quality of life (QoL) and in sociodemographic, clinical and psychological factors associated with impaired QoL in adults with long-standing type 1 diabetes mellitus (DM1). Cross-sectional evaluation in a random cohort of DM1 adult patients from a tertiary care hospital. QoL was evaluated using translated and validated self-administered Diabetes QoL questionnaire (Es-DQoL), and results transformed into a 0-100 scale. Psychological assessment included a planned psychological interview and self-reported questionnaires (Beck Depression Inventory II, State-Trait Anxiety Inventory Form Y, Fear of hypoglycaemia Scale, Medical Outcomes Study Social Support Survey). A total of 312 patients (51.6% male; 38.2 ± 12.7 years; HbA1c 7.5 ± 1.1% (58.5 ± 14.2 mmol/mol); 20.4 ± 12.0 years of DM1) were included in the analysis. Male and female subgroups showed similar sociodemographic and diabetes-related features and comparable social support. Among female patients, higher frequency of depression [31.7% (IC95% 26.2-40.8) vs. 14.9% (IC95% 10.1-20.8), p  Adult women with long-standing DM1 showed lower QoL probably related to higher frequency and severity of psychopathological syndromes. Depressive and anxious symptoms and, among women, exposure to glycemic excursions were identified as modifiable, QoL-related variables. Educational, technological and psychological interventions are needed in order to improve QoL in DM1 patients. SN 1758-5996 YR 2020 FD 2020-07-17 LK https://hdl.handle.net/10668/27961 UL https://hdl.handle.net/10668/27961 LA en DS RISalud RD Apr 7, 2025