RT Journal Article
T1 Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect
A1 Rodriguez-Perez, Maria Dolores
A1 Lopez-Villodres, Juan Antonio
A1 Arrebola, Maria Monsalud
A1 Martin-Aurioles, Esther
A1 Fernandez-Prior, Africa
A1 Bermudez-Oria, Alejandra
A1 Rios, Maria Carmen
A1 de la Cruz, Jose Pedro
A1 Gonzalez-Correa, Jose Antonio
K1 hydroxytyrosol
K1 diabetes
K1 nephropathy
K1 virgin olive oil
K1 Oxidative stress
K1 Induced nephrotoxicity
K1 Mediterranean diet
K1 Rat model
K1 Nephropathy
K1 Apoptosis
AB The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administration, proteinuria was significantly reduced (67-73%), calculated creatinine clearance was significantly increased (26-38%), and the glomerular volume and glomerulosclerosis index were decreased (20-30%). Hydroxytyrosol reduced oxidative and nitrosative stress variables and thromboxane metabolite production. Statistical correlations were found between biochemical and kidney function variables. Oral administration of 1 and 5 mg/kg/day of hydroxytyrosol produced an antioxidant and nephroprotective effect in an experimental model of type 1-like diabetes mellitus. The nephroprotective effect was significantly associated with the systemic and renal antioxidant action of hydroxytyrosol, which also influenced eicosanoid production.
PB Mdpi
YR 2021
FD 2021-11-01
LK https://hdl.handle.net/10668/26787
UL https://hdl.handle.net/10668/26787
LA en
DS RISalud
RD Apr 17, 2025