%0 Journal Article
%A Rodriguez-Perez, Maria Dolores
%A Lopez-Villodres, Juan Antonio
%A Arrebola, Maria Monsalud
%A Martin-Aurioles, Esther
%A Fernandez-Prior, Africa
%A Bermudez-Oria, Alejandra
%A Rios, Maria Carmen
%A de la Cruz, Jose Pedro
%A Gonzalez-Correa, Jose Antonio
%T Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect
%D 2021
%U https://hdl.handle.net/10668/26787
%X The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administration, proteinuria was significantly reduced (67-73%), calculated creatinine clearance was significantly increased (26-38%), and the glomerular volume and glomerulosclerosis index were decreased (20-30%). Hydroxytyrosol reduced oxidative and nitrosative stress variables and thromboxane metabolite production. Statistical correlations were found between biochemical and kidney function variables. Oral administration of 1 and 5 mg/kg/day of hydroxytyrosol produced an antioxidant and nephroprotective effect in an experimental model of type 1-like diabetes mellitus. The nephroprotective effect was significantly associated with the systemic and renal antioxidant action of hydroxytyrosol, which also influenced eicosanoid production.
%K hydroxytyrosol
%K diabetes
%K nephropathy
%K virgin olive oil
%K Oxidative stress
%K Induced nephrotoxicity
%K Mediterranean diet
%K Rat model
%K Nephropathy
%K Apoptosis
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