RT Journal Article
T1 Why Are Viscosity and Nonlinearity Bound to Make an Impact in Clinical Elastographic Diagnosis?
A1 Rus, Guillermo
A1 Faris, Inas H.
A1 Torres, Jorge
A1 Callejas, Antonio
A1 Melchor, Juan
K1 Elastography
K1 Soft tissue
K1 Nonlinearity
K1 Viscoelasticity
K1 Diagnóstico por imagen de elasticidad
K1 Tejidos
K1 Sustancias viscoelásticas
K1 Vicosidad
K1 Elasticidad
AB The adoption of multiscale approaches by the biomechanical community has caused a major improvement in quality in the mechanical characterization of soft tissues. The recent developments in elastography techniques are enabling in vivo and non-invasive quantification of tissues' mechanical properties. Elastic changes in a tissue are associated with a broad spectrum of pathologies, which stems from the tissue microstructure, histology and biochemistry. This knowledge is combined with research evidence to provide a powerful diagnostic range of highly prevalent pathologies, from birth and labor disorders (prematurity, induction failures, etc.), to solid tumors (e.g., prostate, cervix, breast, melanoma) and liver fibrosis, just to name a few. This review aims to elucidate the potential of viscous and nonlinear elastic parameters as conceivable diagnostic mechanical biomarkers. First, by providing an insight into the classic role of soft tissue microstructure in linear elasticity; secondly, by understanding how viscosity and nonlinearity could enhance the current diagnosis in elastography; and finally, by compounding preliminary investigations of those elastography parameters within different technologies. In conclusion, evidence of the diagnostic capability of elastic parameters beyond linear stiffness is gaining momentum as a result of the technological and imaging developments in the field of biomechanics.
PB MDPI
YR 2020
FD 2020-04-22
LK http://hdl.handle.net/10668/3601
UL http://hdl.handle.net/10668/3601
LA en
NO Rus G, Faris IH, Torres J, Callejas A, Melchor J. Why Are Viscosity and Nonlinearity Bound to Make an Impact in Clinical Elastographic Diagnosis? Sensors. 2020 Apr 22;20(8):2379
DS RISalud
RD Apr 9, 2025