RT Journal Article
T1 Anemonia sulcata and Its Symbiont Symbiodinium as a Source of Anti-Tumor and Anti-Oxoxidant Compounds for Colon Cancer Therapy: A Preliminary in Vitro Study
A1 Cabeza, Laura
A1 Peña, Mercedes
A1 Martínez, Rosario
A1 Mesas, Cristina
A1 Galisteo, Milagros
A1 Perazzoli, Gloria
A1 Prados, Jose
A1 Porres, Jesús M.
A1 Melguizo, Consolación
K1 Anemonia sulcata
K1 Symbiodinium
K1 Antioxidant activity
K1 Antitumor activity
K1 Colorectal cancer
K1 Cell death
K1 Digestion
K1 Anemone
K1 Antioxidantes
K1 Neoplasias colorrectales
K1 Muerte celular
K1 Digestión
AB Recently, invertebrate marine species have been investigated for the presence of natural products with antitumor activity. We analyzed the invertebrate Anemonia sulcata with (W) and without (W/O) the presence of its microalgal symbiont Symbiodinium as a source of bioactive compounds that may be applied in the therapy and/or prevention of colorectal cancer (CRC). Animals were mechanically homogenized and subjected to ethanolic extraction. The proximate composition and fatty acid profile were determined. In addition, an in vitro digestion was performed to study the potentially dialyzable fraction. The antioxidant and antitumor activity of the samples and the digestion products were analyzed in CRC cells in vitro. Our results show a high concentration of polyunsaturated fatty acid in the anemone and a great antioxidant capacity, which demonstrated the ability to prevent cell death and a high antitumor activity of the crude homogenates against CRC cells and multicellular tumor spheroids, especially W/O symbiont. These preliminary results support that Anemonia sulcata could be a source of bioactive compounds with antioxidant and antitumor potential against CRC and that the absence of its symbiont may enhance these properties. Further studies will be necessary to define the bioactive compounds of Anemonia sulcata and their mechanisms of action.
PB MDPI
YR 2021
FD 2021-02-08
LK http://hdl.handle.net/10668/4088
UL http://hdl.handle.net/10668/4088
LA en
NO Cabeza L, Peña M, Martínez R, Mesas C, Galisteo M, Perazzoli G, et al. Anemonia sulcata and Its Symbiont Symbiodinium as a Source of Anti-Tumor and Anti-Oxoxidant Compounds for Colon Cancer Therapy: A Preliminary in Vitro Study. Biology. 2021 Feb 8;10(2):134.
DS RISalud
RD Apr 8, 2025