RT Journal Article
T1 Evolution of Serum Acute-Phase Glycoproteins Assessed by 1H-NMR in HIV Elite Controllers.
A1 Malo, Ana-Irene
A1 Peraire, Joaquim
A1 Ruiz-Mateos, Ezequiel
A1 Masip, Jenifer
A1 Amigó, Núria
A1 Alcamí, José
A1 Moreno, Santiago
A1 Girona, Josefa
A1 García-Pardo, Graciano
A1 Reig, Rosaura
A1 Vidal, Francesc
A1 Castro, Antoni
A1 Masana, Lluís
A1 Rull, Anna
K1 HIV
K1 acute-phase glycoproteins
K1 elite controllers
K1 inflammation
K1 proton nuclear magnetic resonance
AB Elite controllers (ECs) are an exceptional group of people living with HIV (PLWH) who maintain undetectable viral loads (VLs) despite not being on antiretroviral therapy (ART). However, this phenotype is heterogeneous, with some of these subjects losing virological control over time. In this longitudinal retrospective study, serum acute-phase glycoprotein profile assessed by proton nuclear magnetic resonance (1H-NMR) was determined in 11 transient controllers (TCs) who spontaneously lost virological control and 11 persistent controllers (PCs) who persistently maintained virological control over time. Both PCs and TCs showed similar acute-phase glycoprotein profiles, even when TCs lost the virological control (GlycB, p = 0.824 and GlycA, p = 0.710), and the serum acute-phase glycoprotein signature in PCs did not differ from that in HIV-negative subjects (GlycB, p = 0.151 and GlycA, p = 0.243). Differences in serum glycoproteins A and B were significant only in ECs compared to HIV-typical progressors (TPs) with
YR 2021
FD 2021-09-28
LK https://hdl.handle.net/10668/27831
UL https://hdl.handle.net/10668/27831
LA en
DS RISalud
RD Apr 8, 2025