RT Journal Article
T1 Retinoprotective Effect of Wild Olive (Acebuche) Oil-Enriched Diet against Ocular Oxidative Stress Induced by Arterial Hypertension.
A1 Santana-Garrido, Álvaro
A1 Reyes-Goya, Claudia
A1 Pérez-Camino, M Carmen
A1 André, Helder
A1 Mate, Alfonso
A1 Vázquez, Carmen M
K1 NADPH (nicotinamide adenine dinucleotide phosphate) oxidase
K1 acebuche
K1 arterial hypertension
K1 nitric oxide
K1 oxidative stress
K1 retina
K1 wild olive oil
AB Oxidative stress plays an important role in the pathogenesis of ocular diseases, including hypertensive eye diseases. The beneficial effects of olive oil on cardiovascular diseases might rely on minor constituents. Currently, very little is known about the chemical composition and/or therapeutic effects of the cultivated olive tree's counterpart, wild olive (also known in Spain as acebuche-ACE). Here, we aimed to analyze the antioxidant and retinoprotective effects of ACE oil on the eye of hypertensive mice made hypertensive via administration of NG-nitro-L-arginine-methyl-ester (L-NAME), which were subjected to a dietary supplementation with either ACE oil or extra virgin olive oil (EVOO) for comparison purposes. Deep analyses of major and minor compounds present in both oils was accompanied by blood pressure monitoring, morphometric analyses, as well as different determinations of oxidative stress-related parameters in retinal layers. Aside from its antihypertensive effect, an ACE oil-enriched diet reduced NADPH (nicotinamide adenine dinucleotide phosphate) oxidase activity/gene/protein expression (with a major implication of NADPH oxidase (NOX)2 isoform) in the retinas of hypertensive mice. Supplementation with ACE oil in hypertensive animals also improved alterations in nitric oxide bioavailability and in antioxidant enzyme profile. Interestingly, our findings show that the use of ACE oil resulted in better outcomes, compared with reference EVOO, against hypertension-related oxidative retinal damage.
SN 2076-3921
YR 2020
FD 2020-09-18
LK https://hdl.handle.net/10668/26806
UL https://hdl.handle.net/10668/26806
LA en
DS RISalud
RD Apr 17, 2025