RT Journal Article
T1 Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study.
A1 Peremiquel-Trillas, Paula
A1 Benavente, Yolanda
A1 Martín-Bustamante, Mayte
A1 Casabonne, Delphine
A1 Pérez-Gómez, Beatriz
A1 Gómez-Acebo, Inés
A1 Oliete-Canela, Anna
A1 Diéguez-Rodríguez, Marta
A1 Tusquets, Ignasi
A1 Amiano, Pilar
A1 Mengual, Lourdes
A1 Ardanaz, Eva
A1 Capelo, Rocío
A1 Molina de la Torre, Antonio J
A1 Salas Trejo, Dolores
A1 Fernández-Tardón, Guillermo
A1 Lope, Virginia
A1 Jimenez-Moleon, José J
A1 Marcos-Gragera, Rafael
A1 Dierssen-Sotos, Trinidad
A1 Azpiri, Mikel
A1 Muñoz, Montse
A1 Guevara, Marcela
A1 Fernández-Villa, Tania
A1 Molina-Barceló, Ana
A1 Aragonés, Nuria
A1 Pollán, Marina
A1 Castaño-Vinyals, Gemma
A1 Alguacil, Juan
A1 Kogevinas, Manolis
A1 de Sanjosé, Silvia
A1 Costas, Laura
K1 Alkylphenolic compounds
K1 Alkylphenols
K1 Breast cancer
K1 Job-exposure matrix
K1 Occupational exposure
K1 Prostate cancer
AB Alkylphenolic compounds are chemicals with endocrine disrupting properties that have been widely used in industry with important changes in their usage over time. Few epidemiologic studies have evaluated the effect of alkylphenolic compounds on human health. We investigated whether occupational exposure to alkylphenolic compounds is associated with breast and prostate cancer. We carried out a population-based case-control study including 1513 incident cases of breast cancer, 1095 of prostate cancer, and 3055 controls, frequency matched by sex, age and region. Occupational exposure to alkylphenolic compounds was estimated using a recently developed job-exposure matrix, which considered different scenarios of exposure and different subtypes of alkylphenolic compounds. History of occupational exposure to alkylphenolic compounds was modestly associated with breast cancer (OR = 1.23; 95% CI = 1.01-1.48). Within the different scenarios, the occupational use of domestic tensioactives was positively associated with breast cancer (OR = 1.28; 95% CI = 1.02-1.60), while occupational exposure in other scenarios showed mostly a suggestion of a similar positive associations. Exposure to nonylphenol ethoxylates was positively associated with breast cancer (OR = 1.21; 95% CI = 1.00-1.47), while exposure to other compounds was uncommon. In general, we did not observe associations between alkylphenolic compounds and prostate cancer, except for a positive association among men occupationally exposed to cosmetic, hair and personal hygiene products. Our findings suggest a modest association between breast cancer risk and occupational exposure to alkylphenolic compounds, and no associations between these compounds and prostate cancer risk. These findings warrant further corroboration in other studies.
YR 2018
FD 2018-12-13
LK http://hdl.handle.net/10668/13312
UL http://hdl.handle.net/10668/13312
LA en
DS RISalud
RD Apr 12, 2025