RT Journal Article
T1 Respiratory Subsets in Patients with Moderate to Severe Acute Respiratory Distress Syndrome for Early Prediction of Death.
A1 Villar, Jesús
A1 Fernández, Cristina
A1 González-Martín, Jesús M
A1 Ferrando, Carlos
A1 Añón, José M
A1 Del Saz-Ortíz, Ana M
A1 Díaz-Lamas, Ana
A1 Bueno-González, Ana
A1 Fernández, Lorena
A1 Domínguez-Berrot, Ana M
A1 Peinado, Eduardo
A1 Andaluz-Ojeda, David
A1 González-Higueras, Elena
A1 Vidal, Anxela
A1 Fernández, M Mar
A1 Mora-Ordoñez, Juan M
A1 Murcia, Isabel
A1 Tarancón, Concepción
A1 Merayo, Eleuterio
A1 Pérez, Alba
A1 Romera, Miguel A
A1 Alba, Francisco
A1 Pestaña, David
A1 Rodríguez-Suárez, Pedro
A1 Fernández, Rosa L
A1 Steyerberg, Ewout W
A1 Berra, Lorenzo
A1 Slutsky, Arthur S
A1 The Spanish Initiative For Epidemiology Stratification And Therapies Of Ards Siesta Network, 
K1 ARDS criteria
K1 lung-protective ventilation
K1 mortality
K1 outcome
K1 prediction
K1 stratification
AB Introduction: In patients with acute respiratory distress syndrome (ARDS), the PaO2/FiO2 ratio at the time of ARDS diagnosis is weakly associated with mortality. We hypothesized that setting a PaO2/FiO2 threshold in 150 mm Hg at 24 h from moderate/severe ARDS diagnosis would improve predictions of death in the intensive care unit (ICU). Methods: We conducted an ancillary study in 1303 patients with moderate to severe ARDS managed with lung-protective ventilation enrolled consecutively in four prospective multicenter cohorts in a network of ICUs. The first three cohorts were pooled (n = 1000) as a testing cohort; the fourth cohort (n = 303) served as a confirmatory cohort. Based on the thresholds for PaO2/FiO2 (150 mm Hg) and positive end-expiratory pressure (PEEP) (10 cm H2O), the patients were classified into four possible subsets at baseline and at 24 h using a standardized PEEP-FiO2 approach: (I) PaO2/FiO2 ≥ 150 at PEEP
SN 2077-0383
YR 2022
FD 2022-09-27
LK http://hdl.handle.net/10668/21351
UL http://hdl.handle.net/10668/21351
LA en
DS RISalud
RD Apr 17, 2025