%0 Journal Article
%A Villar, Jesús
%A Fernández, Cristina
%A González-Martín, Jesús M
%A Ferrando, Carlos
%A Añón, José M
%A Del Saz-Ortíz, Ana M
%A Díaz-Lamas, Ana
%A Bueno-González, Ana
%A Fernández, Lorena
%A Domínguez-Berrot, Ana M
%A Peinado, Eduardo
%A Andaluz-Ojeda, David
%A González-Higueras, Elena
%A Vidal, Anxela
%A Fernández, M Mar
%A Mora-Ordoñez, Juan M
%A Murcia, Isabel
%A Tarancón, Concepción
%A Merayo, Eleuterio
%A Pérez, Alba
%A Romera, Miguel A
%A Alba, Francisco
%A Pestaña, David
%A Rodríguez-Suárez, Pedro
%A Fernández, Rosa L
%A Steyerberg, Ewout W
%A Berra, Lorenzo
%A Slutsky, Arthur S
%A The Spanish Initiative For Epidemiology Stratification And Therapies Of Ards Siesta Network,
%T Respiratory Subsets in Patients with Moderate to Severe Acute Respiratory Distress Syndrome for Early Prediction of Death.
%D 2022
%@ 2077-0383
%U http://hdl.handle.net/10668/21351
%X Introduction: In patients with acute respiratory distress syndrome (ARDS), the PaO2/FiO2 ratio at the time of ARDS diagnosis is weakly associated with mortality. We hypothesized that setting a PaO2/FiO2 threshold in 150 mm Hg at 24 h from moderate/severe ARDS diagnosis would improve predictions of death in the intensive care unit (ICU). Methods: We conducted an ancillary study in 1303 patients with moderate to severe ARDS managed with lung-protective ventilation enrolled consecutively in four prospective multicenter cohorts in a network of ICUs. The first three cohorts were pooled (n = 1000) as a testing cohort; the fourth cohort (n = 303) served as a confirmatory cohort. Based on the thresholds for PaO2/FiO2 (150 mm Hg) and positive end-expiratory pressure (PEEP) (10 cm H2O), the patients were classified into four possible subsets at baseline and at 24 h using a standardized PEEP-FiO2 approach: (I) PaO2/FiO2 ≥ 150 at PEEP
%K ARDS criteria
%K lung-protective ventilation
%K mortality
%K outcome
%K prediction
%K stratification
%~