RT Journal Article
T1 Clinical research tools in pediatric oncology: challenges and opportunities.
A1 de Rojas, Teresa
A1 Neven, Anouk
A1 Towbin, Alexander J
A1 Carceller, Fernando
A1 Bautista, Francisco
A1 Riedl, David
A1 Sodergren, Samantha
A1 Darlington, Anne-Sophie
A1 Fernandez-Teijeiro, Ana
A1 Moreno, Lucas
K1 AYA oncology
K1 CTCAE
K1 Childhood cancer
K1 Quality assurance
K1 Quality of life
K1 RECIST
AB Survival for childhood cancers has improved significantly over the last decades. However, patient outcomes have plateaued over the last decade for difficult-to-treat diseases. With high cure rates, decreasing long-term toxicities and sequelae remains crucial. Since many advances in childhood cancer research come from the adult oncology world, one of the key areas is improving the adaptation of tools that are essential for clinical trial conduct that were developed for adults into pediatrics. These include tools to evaluate toxicity, quality of life, radiological response, statistical methodology, or indicators of cancer care quality. In this review, we present ongoing international efforts to validate and adapt these tools for children and adolescents and discuss remaining challenges. These efforts will hopefully accelerate and improve the quality of pediatric oncology research in the upcoming years.
YR 2020
FD 2020
LK http://hdl.handle.net/10668/14957
UL http://hdl.handle.net/10668/14957
LA en
DS RISalud
RD Apr 5, 2025