RT Journal Article
T1 Severe manifestations of SARS-CoV-2 in children and adolescents: from COVID-19 pneumonia to multisystem inflammatory syndrome: a multicentre study in pediatric intensive care units in Spain.
A1 García-Salido, Alberto
A1 de Carlos Vicente, Juan Carlos
A1 Belda Hofheinz, Sylvia
A1 Balcells Ramírez, Joan
A1 Slöcker Barrio, María
A1 Leóz Gordillo, Inés
A1 Hernández Yuste, Alexandra
A1 Guitart Pardellans, Carmina
A1 Cuervas-Mons Tejedor, Maite
A1 Huidobro Labarga, Beatriz
A1 Vázquez Martínez, José Luís
A1 Gutiérrez Jimeno, Míriam
A1 Oulego-Erróz, Ignacio
A1 Trastoy Quintela, Javier
A1 Medina Monzón, Carmen
A1 Medina Ramos, Laura
A1 Holanda Peña, María Soledad
A1 Gil-Antón, Javier
A1 Sorribes Ortí, Clara
A1 Flores González, José Carlos
A1 Hernández Palomo, Rosa María
A1 Sánchez Ganfornina, Inma
A1 Fernández Romero, Emilia
A1 García-Besteiro, María
A1 López-Herce Cid, Jesús
A1 González Cortés, Rafael
A1 Spanish Pediatric Intensive Care Society working group on SARS-CoV-2 infection, 
K1 Children
K1 Critical care
K1 Kawasaki disease
K1 Pediatric multisystem inflammatory syndrome temporally associated with COVID-19
K1 SARS-CoV-2
K1 Shock
K1 Toxic shock syndrome
AB Multisystem inflammatory syndrome temporally associated with COVID-19 (MIS-C) has been described as a novel and often severe presentation of SARS-CoV-2 infection in children. We aimed to describe the characteristics of children admitted to Pediatric Intensive Care Units (PICUs) presenting with MIS-C in comparison with those admitted with SARS-CoV-2 infection with other features such as COVID-19 pneumonia. A multicentric prospective national registry including 47 PICUs was carried out. Data from children admitted with confirmed SARS-CoV-2 infection or fulfilling MIS-C criteria (with or without SARS-CoV-2 PCR confirmation) were collected. Clinical, laboratory and therapeutic features between MIS-C and non-MIS-C patients were compared. Seventy-four children were recruited. Sixty-one percent met MIS-C definition. MIS-C patients were older than non-MIS-C patients (p = 0.002): 9.4 years (IQR 5.5-11.8) vs 3.4 years (IQR 0.4-9.4). A higher proportion of them had no previous medical history of interest (88.2% vs 51.7%, p = 0.005). Non-MIS-C patients presented more frequently with respiratory distress (60.7% vs 13.3%, p  MIS-C seems to be the most frequent presentation among critically ill children with SARS-CoV-2 infection. MIS-C patients are older and usually healthy. They show a higher prevalence of gastrointestinal symptoms and shock and are more likely to receive vasoactive drugs and immunomodulators and less likely to need mechanical ventilation than non-MIS-C patients.
YR 2020
FD 2020-11-26
LK http://hdl.handle.net/10668/16674
UL http://hdl.handle.net/10668/16674
LA en
DS RISalud
RD Apr 11, 2025