%0 Journal Article
%A Garcia-Salido, Alberto
%A de-Carlos-Vicente, Juan Carlos
%A Belda-Hofheinz, Sylvia
%A Balcells-Ramirez, Joan
%A Slocker-Barrio, Maria
%A Leoz-Gordillo, Ines
%A Hernandez-Yuste, Alexandra
%A Guitart-Pardellans, Carmina
%A Cuervas-Mons-Tejedor, Maite
%A Huidobro-Labarga, Beatriz
%A Vazquez Martinez, Jose Luis
%A Gutierrez Jimeno, Míriam
%A Oulego-Erroz, Ignacio
%A Trastoy-Quintela, Javier
%A Medina-Monzon, Carmen
%A Medina-Ramos, Laura
%A Holanda-Peña, Maria Soledad
%A Gil-Anton, Javier
%A Sorribes-Orti, Clara
%A Flores-Gonzalez, Jose Carlos
%A Hernandez-Palomo, Rosa Maria
%A Sanchez-Ganfornina, Inma
%A Fernandez-Romero, Emilia
%A Garcia-Besteiro, Maria
%A Lopez-Herce Cid, Jesus
%A Gonzalez-Cortes, Rafael
%T Severe manifestations of SARS-CoV-2 in children and adolescents: from COVID-19 pneumonia to multisystem inflammatory syndrome: a multicentre study in pediatric intensive care units in Spain.
%D 2020
%U http://hdl.handle.net/10668/16674
%X Multisystem inflammatory syndrome temporally associated with COVID-19 (MIS-C) has been described as a novel and often severe presentation of SARS-CoV-2 infection in children. We aimed to describe the characteristics of children admitted to Pediatric Intensive Care Units (PICUs) presenting with MIS-C in comparison with those admitted with SARS-CoV-2 infection with other features such as COVID-19 pneumonia. A multicentric prospective national registry including 47 PICUs was carried out. Data from children admitted with confirmed SARS-CoV-2 infection or fulfilling MIS-C criteria (with or without SARS-CoV-2 PCR confirmation) were collected. Clinical, laboratory and therapeutic features between MIS-C and non-MIS-C patients were compared. Seventy-four children were recruited. Sixty-one percent met MIS-C definition. MIS-C patients were older than non-MIS-C patients (p = 0.002): 9.4 years (IQR 5.5-11.8) vs 3.4 years (IQR 0.4-9.4). A higher proportion of them had no previous medical history of interest (88.2% vs 51.7%, p = 0.005). Non-MIS-C patients presented more frequently with respiratory distress (60.7% vs 13.3%, p  MIS-C seems to be the most frequent presentation among critically ill children with SARS-CoV-2 infection. MIS-C patients are older and usually healthy. They show a higher prevalence of gastrointestinal symptoms and shock and are more likely to receive vasoactive drugs and immunomodulators and less likely to need mechanical ventilation than non-MIS-C patients.
%K Children
%K Critical care
%K Kawasaki disease
%K Pediatric multisystem inflammatory syndrome temporally associated with COVID-19
%K SARS-CoV-2
%K Shock
%K Toxic shock syndrome
%~