RT Journal Article
T1 Predictive value of control of COPD for risk of exacerbations: An international, prospective study.
A1 Miravitlles, Marc
A1 Sliwinski, Pawel
A1 Rhee, Chin Kook
A1 Costello, Richard W
A1 Carter, Victoria
A1 Tan, Jessica H Y
A1 Lapperre, Therese S
A1 Alcazar, Bernardino
A1 Gouder, Caroline
A1 Esquinas, Cristina
A1 García-Rivero, Juan Luis
A1 Kemppinen, Anu
A1 Tee, Augustine
A1 Roman-Rodríguez, Miguel
A1 Soler-Cataluña, Juan José
A1 Price, David B
A1 Respiratory Effectiveness Group (REG), 
K1 Chronic Obstructive Pulmonary Disease Assessment Test
K1 clinical control status
K1 dyspnoea
K1 exacerbations
K1 prevention
AB The concept of clinical control in COPD has been developed to help in treatment decisions, but it requires validation in prospective studies. This international, multicentre, prospective study aimed to validate the concept of control in COPD. Patients with COPD were classified as controlled/uncontrolled by clinical criteria or CAT scores at baseline and followed up for 18 months. The main outcome was the difference in rate of a composite endpoint of moderate and severe exacerbations or death over the 18-month follow-up period. A total of 307 patients were analysed (mean age = 68.6 years and mean FEV1 % = 52.5%). Up to 65% and 37.9% of patients were classified as controlled by clinical criteria or CAT, respectively. Controlled patients had significantly less exacerbations during follow-up (by clinical criteria: 1.1 vs 2.6, P  Control status, defined by easy-to-obtain clinical criteria, is predictive of future exacerbation risk and time to the next exacerbation. The concept of control can be used in clinical practice at each clinical visit as a complement to the current recommendations of initial treatment proposed by guidelines.
YR 2020
FD 2020-04-06
LK http://hdl.handle.net/10668/15324
UL http://hdl.handle.net/10668/15324
LA en
DS RISalud
RD Apr 11, 2025