RT Journal Article
T1 Plasmidic qnr Genes Confer Clinical Resistance to Ciprofloxacin under Urinary Tract Physiological Conditions
A1 Martin-Gutierrez, Guillermo
A1 Manuel Rodriguez-Martinez, Jose
A1 Pascual, Alvaro
A1 Rodriguez-Beltran, Jeronimo
A1 Blazquez, Jesus
K1 ciprofloxacin
K1 Escherichia coli
K1 MIC
K1 pH
K1 qnr
K1 urinary tract infection
K1 Mediated quinolone resistance
K1 Fluoroquinolone resistance
K1 Escherichia-coli
K1 Klebsiella-pneumoniae
K1 Aac(6')-ib-cr
K1 Epidemiology
K1 Infections
K1 Mutations
AB Escherichia coli variants expressing plasmid- mediated qnr genes are usually susceptible to fluoroquinolones by standard susceptibility testing. Here we show that, under specific urinary tract physiological conditions, susceptible laboratory and clinical strains harboring qnr determinants become fully resistant to ciprofloxacin (CIP). Therefore, physiological conditions, mainly urine pH values, should be considered when performing susceptibility testing of CIP activity against E. coli in treating urinary tract infection (UTI) and for selecting appropriate antibiotics for UTI treatment.
PB Amer soc microbiology
SN 0066-4804
YR 2017
FD 2017-04-01
LK http://hdl.handle.net/10668/19015
UL http://hdl.handle.net/10668/19015
LA en
DS RISalud
RD Apr 13, 2025