RT Journal Article
T1 Comparison of abdominal adiposity and overall obesity in relation to risk of small intestinal cancer in a European Prospective Cohort.
A1 Lu, Yunxia
A1 Cross, Amanda J
A1 Murphy, Neil
A1 Freisling, Heinz
A1 Travis, Ruth C
A1 Ferrari, Pietro
A1 Katzke, Verena A
A1 Kaaks, Rudolf
A1 Olsson, Åsa
A1 Johansson, Ingegerd
A1 Renström, Frida
A1 Panico, Salvatore
A1 Pala, Valeria
A1 Palli, Domenico
A1 Tumino, Rosario
A1 Peeters, Petra H
A1 Siersema, Peter D
A1 Bueno-de-Mesquita, H B
A1 Trichopoulou, Antonia
A1 Klinaki, Eleni
A1 Tsironis, Christos
A1 Agudo, Antonio
A1 Navarro, Carmen
A1 Sanchez-Perez, Maria-Jose
A1 Barricarte, Aurelio
A1 Boutron-Ruault, Marie-Christine
A1 Fagherazzi, Guy
A1 Racine, Antoine
A1 Weiderpass, Elisabete
A1 Gunter, Marc J
A1 Riboli, Elio
K1 Abdominal obesity
K1 Cancer
K1 Obesity
K1 Small intestine
AB The etiology of small intestinal cancer (SIC) is largely unknown, and there are very few epidemiological studies published to date. No studies have investigated abdominal adiposity in relation to SIC. We investigated overall obesity and abdominal adiposity in relation to SIC in the European Prospective Investigation into Cancer and Nutrition (EPIC), a large prospective cohort of approximately half a million men and women from ten European countries. Overall obesity and abdominal obesity were assessed by body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR). Multivariate Cox proportional hazards regression modeling was performed to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs). Stratified analyses were conducted by sex, BMI, and smoking status. During an average of 13.9 years of follow-up, 131 incident cases of SIC (including 41 adenocarcinomas, 44 malignant carcinoid tumors, 15 sarcomas and 10 lymphomas, and 21 unknown histology) were identified. WC was positively associated with SIC in a crude model that also included BMI (HR per 5-cm increase = 1.20, 95 % CI 1.04, 1.39), but this association attenuated in the multivariable model (HR 1.18, 95 % CI 0.98, 1.42). However, the association between WC and SIC was strengthened when the analysis was restricted to adenocarcinoma of the small intestine (multivariable HR adjusted for BMI = 1.56, 95 % CI 1.11, 2.17). There were no other significant associations. WC, rather than BMI, may be positively associated with adenocarcinomas but not carcinoid tumors of the small intestine. Abdominal obesity is a potential risk factor for adenocarcinoma in the small intestine.
YR 2016
FD 2016-06-13
LK http://hdl.handle.net/10668/10168
UL http://hdl.handle.net/10668/10168
LA en
DS RISalud
RD Apr 10, 2025