RT Journal Article
T1 A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study.
A1 Papadimitriou, Nikos
A1 Muller, David
A1 van den Brandt, Piet A
A1 Geybels, Milan
A1 Patel, Chirag J
A1 Gunter, Marc J
A1 Lopez, David S
A1 Key, Timothy J
A1 Perez-Cornago, Aurora
A1 Ferrari, Pietro
A1 Vineis, Paolo
A1 Weiderpass, Elisabete
A1 Boeing, Heiner
A1 Agudo, Antonio
A1 Sanchez-Perez, Maria-Jose
A1 Overvad, Kim
A1 Kühn, Tilman
A1 Fortner, Renee T
A1 Palli, Domenico
A1 Drake, Isabel
A1 Bjartell, Anders
A1 Santiuste, Carmen
A1 Bueno-de-Mesquita, Bas H
A1 Krogh, Vittorio
A1 Tjønneland, Anne
A1 Lauritzen, Dorthe Furstrand
A1 Gurrea, Aurelio Barricarte
A1 Quirós, José Ramón
A1 Stattin, Pär
A1 Trichopoulou, Antonia
A1 Martimianaki, Georgia
A1 Karakatsani, Anna
A1 Thysell, Elin
A1 Johansson, Ingegerd
A1 Ricceri, Fulvio
A1 Tumino, Rosario
A1 Larrañaga, Nerea
A1 Khaw, Kay Tee
A1 Riboli, Elio
A1 Tzoulaki, Ioanna
A1 Tsilidis, Konstantinos K
K1 Cohort study
K1 Diet
K1 Epidemiology
K1 Nutrition
K1 Prostate cancer
AB The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR  A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS. Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature.
YR 2019
FD 2019-11-08
LK http://hdl.handle.net/10668/14661
UL http://hdl.handle.net/10668/14661
LA en
DS RISalud
RD Apr 10, 2025