RT Journal Article
T1 Bottlenecks in the Efficient Use of Advanced Therapy Medicinal Products Based on Mesenchymal Stromal Cells.
A1 Escacena, Natalia
A1 Quesada-Hernández, Elena
A1 Capilla-Gonzalez, Vivian
A1 Soria, Bernat
A1 Hmadcha, Abdelkrim
K1 Cell therapy
K1 Advanced therapy medicinal product
K1 Mesenchymal stem cells
K1 Tratamiento Basado en trasplante de células y tejidos
K1 Células del Estroma Mesenquimatoso
K1 Trasplante de Células Madre Mesenquimatosas
K1 Homeostasis
AB Mesenchymal stromal cells (MSCs) have been established as promising candidate sources of universal donor cells for cell therapy due to their contributions to tissue and organ homeostasis, repair, and support by self-renewal and multidifferentiation, as well as by their anti-inflammatory, antiproliferative, immunomodulatory, trophic, and proangiogenic properties. Various diseases have been treated by MSCs in animal models. Additionally, hundreds of clinical trials related to the potential benefits of MSCs are in progress. However, although all MSCs are considered suitable to exert these functions, dissimilarities have been found among MSCs derived from different tissues. The same levels of efficacy and desired outcomes have not always been achieved in the diverse studies that have been performed thus far. Moreover, autologous MSCs can be affected by the disease status of patients, compromising their use. Therefore, collecting information regarding the characteristics of MSCs obtained from different sources and the influence of the host (patient) medical conditions on MSCs is important for assuring the safety and efficacy of cell-based therapies. This review provides relevant information regarding factors to consider for the clinical application of MSCs.
PB Hindawi Publishing Corporation
YR 2015
FD 2015
LK http://hdl.handle.net/10668/2242
UL http://hdl.handle.net/10668/2242
LA en
NO Escacena N, Quesada-Hernández E, Capilla-Gonzalez V, Soria B, Hmadcha A. Bottlenecks in the Efficient Use of Advanced Therapy Medicinal Products Based on Mesenchymal Stromal Cells. Stem Cells Int; 2015: Article ID 895714
NO Journal Article; Review;
DS RISalud
RD Apr 16, 2025