RT Journal Article
T1 Mutational profile of primary breast diffuse large B-cell lymphoma
A1 Franco, Fernando
A1 Gonzalez-Rincon, Julia
A1 Lavernia, Javier
A1 Garcia, Juan F.
A1 Martin, Paloma
A1 Bellas, Carmen
A1 Piris, Miguel A.
A1 Pedrosa, Lucia
A1 Miramon, Jose
A1 Gomez-Codina, Jose
A1 Rodriguez-Abreu, Delvys
A1 Machado, Isidro
A1 Illueca, Carmen
A1 Alfaro, Jesus
A1 Provencio, Mariano
A1 Sanchez-Beato, Margarita
K1 primary breast lymphoma
K1 diffuse large B-cell lymphoma
K1 cell of origin
K1 NFkB pathway
K1 PIM1
K1 Prognostic-factors
K1 Clinical-trial
K1 Card11
K1 Malignancies
K1 Expression
AB Primary breast lymphoma is a rare form of extra-nodal lymphoid neoplasm. The most common histological type is the diffuse large B-cell lymphoma, which represents 60-80% of all the cases. Our study analyzes the mutational profile of the primary lymphoma of the breast through targeted massive sequencing with a panel of 38 genes in a group of 17 patients with primary breast diffuse large B-cell lymphoma. Seventy-point-five percent of the patients presented with stage IE and 29.5% with stage IIE. 44% of the cases correspond to lymphomas with germinal center phenotype and 33.3% to activated B-cell. The genes with a higher mutational frequency include PIM1 (in 50% of the analyzed samples), MYD88 (39%), CD79B, PRDM1 and CARD11 (17%), KMT2D, TNFIAP3 and CREBBP (11%). The profile of mutant genes involves mostly the NF kappa B signaling pathway. The high frequency of mutations in PIM1 compared with other lymphomas may have implications in the clinical presentation and evolution of this type of lymphoma.
PB Impact journals llc
YR 2017
FD 2017-11-28
LK http://hdl.handle.net/10668/19446
UL http://hdl.handle.net/10668/19446
LA en
DS RISalud
RD Apr 19, 2025