RT Journal Article
T1 Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer's Disease.
A1 Bonaterra-Pastra, Anna
A1 Fernandez-de-Retana, Sofia
A1 Rivas-Urbina, Andrea
A1 Puig, Nuria
A1 Benitez, Sonia
A1 Pancorbo, Olalla
A1 Rodriguez-Luna, David
A1 Pujadas, Francesc
A1 Freijo, Maria Del Mar
A1 Tur, Silvia
A1 Martinez-Zabaleta, Maite
A1 Cardona-Portela, Pere
A1 Vera, Rocio
A1 Lebrato-Hernandez, Lucia
A1 Arenillas, Juan F
A1 Perez-Sanchez, Soledad
A1 Montaner, Joan
A1 Sanchez-Quesada, Jose Luis
A1 Hernandez-Guillamon, Mar
K1 Alzheimer’s disease
K1 apolipoproteins
K1 cerebral amyloid angiopathy
K1 lipid profile
K1 lipoprotein composition
AB Cerebral amyloid angiopathy (CAA) refers to beta-amyloid (Aβ) deposition in brain vessels and is clinically the main cause of lobar intracerebral hemorrhage (ICH). Aβ can also accumulate in brain parenchyma forming neuritic plaques in Alzheimer's disease (AD). Our study aimed to determine whether the peripheral lipid profile and lipoprotein composition are associated with cerebral beta-amyloidosis pathology and may reflect biological differences in AD and CAA. For this purpose, lipid and apolipoproteins levels were analyzed in plasma from 51 ICH-CAA patients (collected during the chronic phase of the disease), 60 AD patients, and 60 control subjects. Lipoproteins (VLDL, LDL, and HDL) were isolated and their composition and pro/antioxidant ability were determined. We observed that alterations in the lipid profile and lipoprotein composition were remarkable in the ICH-CAA group compared to control subjects, whereas the AD group presented no specific alterations compared with controls. ICH-CAA patients presented an atheroprotective profile, which consisted of lower total and LDL cholesterol levels. Plasma from chronic ICH-CAA patients also showed a redistribution of ApoC-III from HDL to VLDL and a higher ApoE/ApoC-III ratio in HDL. Whether these alterations reflect a protective response or have a causative effect on the pathology requires further investigation.
PB MDPI AG
SN 2227-9059
YR 2021
FD 2021-01-12
LK http://hdl.handle.net/10668/16978
UL http://hdl.handle.net/10668/16978
LA en
NO Bonaterra-Pastra A, Fernández-de-Retana S, Rivas-Urbina A, Puig N, Benítez S, Pancorbo O, et al. Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer's Disease. Biomedicines. 2021 Jan 12;9(1):72.
DS RISalud
RD Apr 9, 2025