RT Journal Article
T1 Relationship between QT Interval Length and Arterial Stiffness in Systemic Lupus Erythematosus (SLE): A Cross-Sectional Case-Control Study.
A1 Rivera-López, Ricardo
A1 Jiménez-Jáimez, Juan
A1 Sabio, José Mario
A1 Zamora-Pasadas, Mónica
A1 Vargas-Hitos, José Antonio
A1 Martínez-Bordonado, Josefina
A1 Navarrete-Navarrete, Nuria
A1 Fernández, Ricardo Rivera
A1 Sanchez-Cantalejo, Emilio
A1 Jiménez-Alonso, Juan
K1 Aterosclerosis
K1 Estudios transversales
K1 Electrocardiografía
K1 Lupus eritematoso discoide
K1 Rigidez vascular
AB INTRODUCTION AND OBJECTIVESThe QT interval on the electrocardiogram has been shown to be longer in patients with systemic lupus erythematosus (SLE) compared to that of the general population. The clinical significance of this finding is unknown. The aim of this study was to assess the relationship between QT interval and subclinical atherosclerosis, measured by carotid-femoral pulse-wave velocity.MATERIAL AND METHODS93 patients with SLE and 109 healthy women with similar basal characteristics were studied. All patients underwent a 12- lead electrocardiogram, and corrected QT interval (QTc) was measured using the Bazett's formula. The presence of atherosclerosis was evaluated by carotid-femoral pulse-wave velocity.RESULTSClinical basal characteristics were similar in both groups. QTc interval was 415±21.4 milliseconds in all patients, and 407±19.1 milliseconds in the control group (p = 0.007). There was a positive correlation between QTc interval and carotid-femoral pulse-wave velocity (r = 0.235; p = 0.02) in patients with SLE. This association was independent of hypertension and age in a multivariate analysis.CONCLUSIONQTc interval measured by electrocardiogram is prolonged in SLE patients; it is related to subclinical atherosclerosis, measured by carotid-femoral pulse-wave velocity. This measure may help stratify risk in routine clinical practice and select the patients that might benefit from a more aggressive therapy in the prevention of cardiovascular events.
PB Public Library of Science
YR 2016
FD 2016-04-11
LK http://hdl.handle.net/10668/2297
UL http://hdl.handle.net/10668/2297
LA en
NO Rivera-López R, Jiménez-Jáimez J, Sabio JM, Zamora-Pasadas M, Vargas-Hitos JA, Martínez-Bordonado J, et al. Relationship between QT Interval Length and Arterial Stiffness in Systemic Lupus Erythematosus (SLE): A Cross-Sectional Case-Control Study. PLoS ONE. 2016; 11(4):e0152291
NO Journal Article;
DS RISalud
RD Apr 7, 2025