RT Journal Article
T1 Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration.
A1 Paschou, Peristera
A1 Jin, Yin
A1 Müller-Vahl, Kirsten
A1 Möller, Harald E
A1 Rizzo, Renata
A1 Hoekstra, Pieter J
A1 Roessner, Veit
A1 Mol Debes, Nanette
A1 Worbe, Yulia
A1 Hartmann, Andreas
A1 Mir, Pablo
A1 Cath, Danielle
A1 Neuner, Irene
A1 Eichele, Heike
A1 Zhang, Chencheng
A1 Lewandowska, Katarzyna
A1 Munchau, Alexander
A1 Verrel, Julius
A1 Musil, Richard
A1 Silk, Tim J
A1 Hanlon, Colleen A
A1 Bihun, Emily D
A1 Brandt, Valerie
A1 Dietrich, Andrea
A1 Forde, Natalie
A1 Ganos, Christos
A1 Greene, Deanna J
A1 Chu, Chunguang
A1 Grothe, Michel J
A1 Hershey, Tamara
A1 Janik, Piotr
A1 Koller, Jonathan M
A1 Martin-Rodriguez, Juan Francisco
A1 Müller, Karsten
A1 Palmucci, Stefano
A1 Prato, Adriana
A1 Ramkiran, Shukti
A1 Saia, Federica
A1 Szejko, Natalia
A1 Torrecuso, Renzo
A1 Tumer, Zeynep
A1 Uhlmann, Anne
A1 Veselinovic, Tanja
A1 Wolańczyk, Tomasz
A1 Zouki, Jade-Jocelyne
A1 Jain, Pritesh
A1 Topaloudi, Apostolia
A1 Kaka, Mary
A1 Yang, Zhiyu
A1 Drineas, Petros
A1 Thomopoulos, Sophia I
A1 White, Tonya
A1 Veltman, Dick J
A1 Schmaal, Lianne
A1 Stein, Dan J
A1 Buitelaar, Jan
A1 Franke, Barbara
A1 van den Heuvel, Odile
A1 Jahanshad, Neda
A1 Thompson, Paul M
A1 Black, Kevin J
K1 ENIGMA
K1 Tourette syndrome
K1 brain MRI
K1 genetics
K1 neuroimaging
AB Tourette syndrome (TS) is characterized by multiple motor and vocal tics, and high-comorbidity rates with other neuropsychiatric disorders. Obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), major depressive disorder (MDD), and anxiety disorders (AXDs) are among the most prevalent TS comorbidities. To date, studies on TS brain structure and function have been limited in size with efforts mostly fragmented. This leads to low-statistical power, discordant results due to differences in approaches, and hinders the ability to stratify patients according to clinical parameters and investigate comorbidity patterns. Here, we present the scientific premise, perspectives, and key goals that have motivated the establishment of the Enhancing Neuroimaging Genetics through Meta-Analysis for TS (ENIGMA-TS) working group. The ENIGMA-TS working group is an international collaborative effort bringing together a large network of investigators who aim to understand brain structure and function in TS and dissect the underlying neurobiology that leads to observed comorbidity patterns and clinical heterogeneity. Previously collected TS neuroimaging data will be analyzed jointly and integrated with TS genomic data, as well as equivalently large and already existing studies of highly comorbid OCD, ADHD, ASD, MDD, and AXD. Our work highlights the power of collaborative efforts and transdiagnostic approaches, and points to the existence of different TS subtypes. ENIGMA-TS will offer large-scale, high-powered studies that will lead to important insights toward understanding brain structure and function and genetic effects in TS and related disorders, and the identification of biomarkers that could help inform improved clinical practice.
SN 1664-0640
YR 2022
FD 2022-08-18
LK http://hdl.handle.net/10668/20738
UL http://hdl.handle.net/10668/20738
LA en
DS RISalud
RD Apr 7, 2025