%0 Journal Article
%A Arias-de la Rosa, Ivan
%A Escudero-Contreras, Alejandro
%A Ruiz-Ponce, Miriam
%A Cuesta-Lopez, Laura
%A Roman-Rodriguez, Cristobal
%A Perez-Sanchez, Carlos
%A Ruiz-Limon, Patricia
%A Ruiz, Rocio Guzman
%A Leiva-Cepas, Fernando
%A Alcaide, Juan
%A Segui, Pedro
%A Plasencia, Chamaida
%A Martinez-Feito, Ana
%A Font, Pilar
%A Abalos, María C
%A Ortega, Rafaela
%A Malagon, Maria M
%A Tinahones, Francisco J
%A Collantes-Estevez, Eduardo
%A Lopez-Pedrera, Chary
%A Barbarroja, Nuria
%T Pathogenic mechanisms involving the interplay between adipose tissue and auto-antibodies in rheumatoid arthritis.
%D 2022
%U http://hdl.handle.net/10668/22278
%X We aimed to evaluate the association between adipose tissue (AT) dysfunction, autoimmunity, and disease activity in rheumatoid arthritis (RA). A cross-sectional study including 150 RA patients and 50 healthy donors and longitudinal study with 122 RA patients treated with anti-tumor necrosis factor (TNF)-α, anti-interleukin 6 receptor (IL6R) or anti-CD20 therapies for 6 months were carried out. In vitro experiments with human AT and adipocyte and macrophage cell lines were performed. A collagen-induced arthritis mouse model was developed. The insulin resistance and the altered adipocytokine profile were associated with disease activity, the presence of anti-citrullinated proteins anti-bodies (ACPAs), and worse response to therapy in RA. AT in the context of arthritis is characterized by an inflammatory state alongside the infiltration of macrophages and B/plasmatic cells, where ACPAs can have a direct impact, inducing inflammation and insulin resistance in macrophages and promoting a defective adipocyte differentiation, partially restored by biologicals.
%K Health sciences
%K Immunology
%K Rheumatology
%~