TY  - JOUR
AU  - Martínez-Bueno, Manuel
AU  - Alarcón-Riquelme, Marta E
PY  - 2019
DO  - 10.3389/fimmu.2019.00258
UR  - http://hdl.handle.net/10668/13696
T2  - Frontiers in immunology
AB  - The importance of low frequency and rare variation in complex disease genetics is difficult to estimate in patient populations. Genome-wide association studies are therefore, underpowered to detect rare variation. We have used a combined approach of...
LA  - en
KW  - GWAS—genome-wide association study
KW  - SLE
KW  - aggregated case-control enrichment
KW  - imputated rare variation
KW  - sequence kernel association test
KW  - systemic lupus erythematosus
KW  - Alleles
KW  - Case-Control Studies
KW  - Gene Frequency
KW  - Genetic Predisposition to Disease
KW  - Genome-Wide Association Study
KW  - Genotype
KW  - Humans
KW  - Linkage Disequilibrium
KW  - Lupus Erythematosus, Systemic
KW  - Mutation
KW  - Phenotype
KW  - Polymorphism, Single Nucleotide
TI  - Exploring Impact of Rare Variation in Systemic Lupus Erythematosus by a Genome Wide Imputation Approach.
TY  - research article
VL  - 10
ER  -