RT Journal Article
T1 Anti-Inflammatory (M2) Response Is Induced by a sp2-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy.
A1 Cano-Cano, Fatima
A1 Alcalde-Estevez, Elena
A1 Gomez-Jaramillo, Laura
A1 Iturregui, Marta
A1 Sánchez-Fernandez, Elena M
A1 Garcia Fernandez, Jose M
A1 Ortiz Mellet, Carmen
A1 Campos-Caro, Antonio
A1 Lopez-Tinoco, Cristina
A1 Aguilar-Diosdado, Manuel
A1 Valverde, Angela M
A1 Arroba, Ana I
K1 M2 response
K1 Diabetic retinopathy
K1 Immunomodulation
K1 Microglia
K1 sp2-iminosugar glycolipids
AB Diabetic retinopathy (DR) is one of the most common complications of Diabetes Mellitus (DM) and is directly associated with inflammatory processes. Currently, neuro-inflammation is considered an early event in DR and proceeds via microglia polarization. A hallmark of DR is the presence of retinal reactive gliosis. Here we report the beneficial effect of (SS,1R)-1-docecylsulfiny-5N,6O-oxomethylidenenojirimycin ((Ss)-DS-ONJ), a member of the sp2-iminosugar glycolipid (sp2-IGL) family, by decreasing iNOS and inflammasome activation in Bv.2 microglial cells exposed to pro-inflammatory stimuli. Moreover, pretreatment with (Ss)-DS-ONJ increased Heme-oxygenase (HO)-1 as well as interleukin 10 (IL10) expression in LPS-stimulated microglial cells, thereby promoting M2 (anti-inflammatory) response by the induction of Arginase-1. The results strongly suggest that this is the likely molecular mechanism involved in the anti-inflammatory effects of (SS)-DS-ONJ in microglia. (SS)-DS-ONJ further reduced gliosis in retinal explants from type 1 diabetic BB rats, which is consistent with the enhanced M2 response. In conclusion, targeting microglia polarization dynamics in M2 status by compounds with anti-inflammatory activities offers promising therapeutic interventions at early stages of DR.
PB Frontiers Research Foundation
YR 2021
FD 2021-03-01
LK http://hdl.handle.net/10668/17531
UL http://hdl.handle.net/10668/17531
LA en
NO Cano-Cano F, Alcalde-Estévez E, Gómez-Jaramillo L, Iturregui M, Sánchez-Fernández EM, García Fernández JM, et al. Anti-Inflammatory (M2) Response Is Induced by a sp2-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy. Front Immunol. 2021 Mar 18;12:632132
DS RISalud
RD Apr 19, 2025