RT Journal Article
T1 Cortical Visual Evoked Potentials and Growth in Infants Fed with Bioactive Compounds-Enriched Infant Formula: Results from COGNIS Randomized Clinical Trial.
A1 Nieto-Ruiz, Ana
A1 García-Santos, José Antonio
A1 Bermúdez, Mercedes G
A1 Herrmann, Florian
A1 Diéguez, Estefanía
A1 Sepúlveda-Valbuena, Natalia
A1 García, Salomé
A1 Miranda, M Teresa
A1 De-Castellar, Roser
A1 Rodríguez-Palmero, María
A1 Catena, Andrés
A1 Campoy, Cristina
K1 bioactive compounds
K1 breastfeeding
K1 growth
K1 infant formula
K1 visual evoked potentials
AB Postnatal nutrition is essential for growth and neurodevelopment. We analyzed the influence of a new enriched-infant formula with bioactive compounds on growth, neurodevelopment, and visual function (VF) in healthy infants during their first 18 months of life. A total of 170 infants were randomized in the COGNIS randomized clinical trial (RCT) to receive a standard infant formula (SF = 85) or a new experimental infant formula supplemented with functional nutrients (EF = 85). As a control, 50 breastfed infants (BF) were enrolled. Growth patterns were evaluated up to 18 months of life; neurodevelopment was assessed by general movements at 2, 3, and 4 months; VF was measured by cortical visual evoked potentials at 3 and 12 months. No differences in growth and neurodevelopment were found between groups. Regarding VF, SF and EF infants presented prolonged latencies and lower amplitudes in the P100 wave than BF infants. In the EF group, a higher percentage of infants presented response at 7½'of arc at 12 months compared to 3 months of age; a similar proportion of BF and EF infants presented responses at 7½'of arc at 12 months of age. Early nutritional intervention with bioactive compounds could narrow the gap in growth and neurodevelopment between breastfed and formula-fed infants.
YR 2019
FD 2019-10-14
LK http://hdl.handle.net/10668/14800
UL http://hdl.handle.net/10668/14800
LA en
DS RISalud
RD Apr 9, 2025