RT Journal Article
T1 Precision Medicine in House Dust Mite-Driven Allergic Asthma.
A1 Eguiluz-Gracia, Ibon
A1 Palomares, Francisca
A1 Salas, Maria
A1 Testera-Montes, Almudena
A1 Ariza, Adriana
A1 Davila, Ignacio
A1 Bartra, Joan
A1 Mayorga, Cristobalina
A1 Torres, Maria Jose
A1 Rondon, Carmen
K1 allergic asthma
K1 bronchial allergen challenge
K1 house dust mites
K1 local allergic asthma
K1 sublingual allergen immunotherapy
AB House dust mites (HDMs) are the allergenic sources most frequently involved in airway allergy. Nevertheless, not every sensitized patient develops respiratory symptoms upon exposure to HDM, and there is a clinical need to differentiate allergic asthmatics (AAs) from atopic non-allergic asthmatics with HDM sensitization. This differentiation sometimes requires in vivo provocations like the bronchial allergen challenge (BAC). Interestingly, recent data demonstrate that non-atopic patients with asthma can also develop positive BAC results. This novel phenotype has been termed local allergic asthma (LAA). The interest in identifying the allergic triggers of asthma resides in the possibility of administering allergen immunotherapy (AIT). AIT is a disease-modifying intervention, the clinical benefit of which persists after therapy discontinuation. Recently, new modalities of sublingual tablets of HDM immunotherapy registered as pharmaceutical products (HDM-SLIT tablets) have become commercially available. HDM-SLIT tablets have demonstrated a robust effect over critical asthma parameters (dose of inhaled corticosteroids, exacerbations, and safety), thus being recommended by international guidelines for patients with HDM-driven AA. In this review, we will summarize the current knowledge on the phenotype and endotype of HDM-driven AA, and LAA, address the difficulties for BAC implementation in the clinic, and discuss the effects of AIT in AA and LAA.
SN 2077-0383
YR 2020
FD 2020-11-26
LK https://hdl.handle.net/10668/26178
UL https://hdl.handle.net/10668/26178
LA en
DS RISalud
RD Apr 12, 2025