RT Journal Article
T1 Contact sensitization to limonene and linalool hydroperoxides in Spain: a GEIDAC* prospective study.
A1 Deza, Gustavo
A1 García-Bravo, Begoña
A1 Silvestre, Juan F
A1 Pastor-Nieto, Maria A
A1 González-Pérez, Ricardo
A1 Heras-Mendaza, Felipe
A1 Mercader, Pedro
A1 Fernández-Redondo, Virginia
A1 Niklasson, Bo
A1 Giménez-Arnau, Ana M
A1 GEIDAC, 
K1 allergic contact dermatitis
K1 fragrance allergy
K1 hydroperoxides
K1 limonene
K1 linalool
AB Limonene and linalool are common fragrance terpenes widely used in cosmetic, household and hygiene products. Their primary oxidation products formed after air exposure, the hydroperoxides, have been recognized as important contact haptens. To investigate the prevalence of contact allergy to hydroperoxides of limonene (Lim-OOHs) and hydroperoxides of linalool (Lin-OOHs) in Spain, and to define the optimal concentration for screening in consecutive patients. Three different concentrations of Lim-OOHs (0.1%, 0.2% and 0.3% pet.) and Lin-OOHs (0.25%, 0.5% and 1.0% pet.) were simultaneously tested in 3639 consecutive patients at 22 departments of dermatology in Spain. Lim-OOHs at 0.1%, 0.2% and 0.3% yielded positive patch test reactions in 1.4%, 3.4% and 5.1% of the tested patients, respectively; and Lin-OOHs at 0.25%, 0.5% and 1.0% yielded positive reactions in 1.3%, 2.9% and 4.9% of the tested patients, respectively. Few irritant (1.5-1.9%) and doubtful reactions (0.4-0.5%) to both terpene hydroperoxides were registered at the highest concentrations tested. Lim-OOHs and Lin-OOHs can be considered as common causes of contact allergy, and their inclusion in an extended baseline patch test series therefore seems to be appropriate. The patch test preparations of Lim-OOHs 0.3% pet. and Lin-OOHs 1.0% pet. are useful tools for screening of contact sensitization.
YR 2016
FD 2016-11-29
LK http://hdl.handle.net/10668/10649
UL http://hdl.handle.net/10668/10649
LA en
DS RISalud
RD Apr 5, 2025