RT Journal Article
T1 Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study.
A1 Martin-Pelaez, Sandra
A1 Serra-Majem, Lluis
A1 Cano-Ibañez, Naomi
A1 Martinez-Gonzalez, Miguel Angel
A1 Salas-Salvado, Jordi
A1 Corella, Dolores
A1 Lassale, Camille
A1 Martinez, Jose Alfredo
A1 Alonso-Gomez, Angel M
A1 Wärnberg, Julia
A1 Vioque, Jesus
A1 Romaguera, Dora
A1 Lopez-Miranda, Jose
A1 Estruch, Ramon
A1 Tinahones, Francisco J
A1 Lapetra, Jose
A1 Fernandez-Aranda, Fernando
A1 Bueno-Cavanillas, Aurora
A1 Tur, Josep A
A1 Martin, Vicente
A1 Pinto, Xavier
A1 Delgado-Rodriguez, Miguel
A1 Matia, Pilar
A1 Vidal, Josep
A1 Vazquez, Clotilde
A1 Daimiel, Lidia
A1 Ros, Emili
A1 Toledo, Estefania
A1 Nishi, Stephanie K
A1 Sorli, Jose V
A1 Malcampo, Mireia
A1 Zulet, M Angeles
A1 Moreno-Rodriguez, Anai
A1 Cueto-Galan, Raquel
A1 Vivancos-Aparicio, Diego
A1 Colom, Antoni
A1 Garcia-Rios, Antonio
A1 Casas, Rosa
A1 Bernal-Lopez, M Rosa
A1 Santos-Lozano, Jose Manuel
A1 Vazquez, Zenaida
A1 Gomez-Martinez, Carlos
A1 Ortega-Azorin, Carolina
A1 Del Val, Jose Luís
A1 Abete, Itziar
A1 Goikoetxea-Bahon, Amaia
A1 Pascual, Elena
A1 Becerra-Tomas, Nerea
A1 Chillaron, Juan J
A1 Sanchez-Villegas, Almudena
K1 Aged
K1 Cholesterol
K1 Cross-sectional studies
K1 Depression
K1 Diabetes mellitus
AB Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol  Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response. 
PB Public Library of Science
YR 2022
FD 2022-02-13
LK http://hdl.handle.net/10668/20422
UL http://hdl.handle.net/10668/20422
LA en
NO Martín-Peláez S, Serra-Majem L, Cano-Ibáñez N, Martínez-González MÁ, Salas-Salvadó J, Corella D, et al. Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study. PLoS One. 2022 Apr 13;17(4):e0265079
DS RISalud
RD Apr 8, 2025