RT Journal Article
T1 Role of immune escape mechanisms in Hodgkin's lymphoma development and progression: a whole new world with therapeutic implications.
A1 Lejeune, Marylène
A1 Nogales Fernández, Esteban
A1 Henao Carrasco, Fernando
A1 Grueso López, Ana
A1 Illescas Vacas, Ana
A1 Pulla, Mariano Provencio
A1 Callau, Cristina
A1 Álvaro, Tomás
K1 Células dendríticas
K1 Progresión de la enfermedad
K1 Enfermedad de Hodgkin
K1 Huésped inmunocomprometido
K1 Macrófagos
K1 Células de Reed-Sternberg
K1 Microambiente tumoral
AB Hodgkin's lymphoma represents one of the most frequent lymphoproliferative syndromes, especially in young population. Although HL is considered one of the most curable tumors, a sizeable fraction of patients recur after successful upfront treatment or, less commonly, are primarily resistant. This work tries to summarize the data on clinical, histological, pathological, and biological factors in HL, with special emphasis on the improvement of prognosis and their impact on therapeutical strategies. The recent advances in our understanding of HL biology and immunology show that infiltrated immune cells and cytokines in the tumoral microenvironment may play different functions that seem tightly related with clinical outcomes. Strategies aimed at interfering with the crosstalk between tumoral Reed-Sternberg cells and their cellular partners have been taken into account in the development of new immunotherapies that target different cell components of HL microenvironment. This new knowledge will probably translate into a change in the antineoplastic treatments in HL in the next future and hopefully will increase the curability rates of this disease.
PB Hindawi Publishing Corporation
SN 1740-2522
YR 2012
FD 2012
LK http://hdl.handle.net/10668/2078
UL http://hdl.handle.net/10668/2078
LA en
NO de la Cruz-Merino L, Lejeune M, Nogales Fernández E, Henao Carrasco F, Grueso López A, Illescas Vacas A, et al. Role of immune escape mechanisms in Hodgkin's lymphoma development and progression: a whole new world with therapeutic implications. Clin. Dev. Immunol. 2012; 2012:756353
NO Journal Article; Review;
DS RISalud
RD Apr 19, 2025