RT Journal Article
T1 The Role of the Gut Microbiome in Cow's Milk Allergy: A Clinical Approach.
A1 Moriki, Dafni
A1 Francino, Maria Pilar
A1 Koumpagioti, Despoina
A1 Boutopoulou, Barbara
A1 Rufian-Henares, Jose Angel
A1 Priftis, Kostas N
A1 Douros, Konstantinos
K1 cow’s milk allergy
K1 dysbiosis
K1 food allergy
K1 gut microbiome
K1 prebiotics
K1 probiotics
AB Cow's milk allergy (CMA) is the most prevalent food allergy (FA) in infancy and early childhood and can be present with various clinical phenotypes. The significant increase in FA rates recorded in recent decades has been associated with environmental and lifestyle changes that limit microbial exposure in early life and induce changes in gut microbiome composition. Gut microbiome is a diverse community of microbes that colonize the gastrointestinal tract (GIT) and perform beneficial functions for the host. This complex ecosystem interacts with the immune system and has a pivotal role in the development of oral tolerance to food antigens. Emerging evidence indicates that alterations of the gut microbiome (dysbiosis) in early life cause immune dysregulation and render the host susceptible to immune-mediated diseases later in life. Therefore, the colonization of the gut by "healthy" microbes that occurs in the first years of life determines the lifelong health of the host. Here, we present current data on the possible role of the gut microbiome in the development of CMA. Furthermore, we discuss how gut microbiome modification might be a potential strategy for CMA prevention and treatment.
PB MDPI AG
YR 2022
FD 2022-10-26
LK http://hdl.handle.net/10668/21513
UL http://hdl.handle.net/10668/21513
LA en
NO Moriki D, Francino MP, Koumpagioti D, Boutopoulou B, Rufián-Henares JÁ, Priftis KN, et al. The Role of the Gut Microbiome in Cow's Milk Allergy: A Clinical Approach. Nutrients. 2022 Oct 28;14(21):4537.
DS RISalud
RD Apr 18, 2025