RT Journal Article T1 Regular insulin added to total parenteral nutrition vs subcutaneous glargine in non-critically ill diabetic inpatients, a multicenter randomized clinical trial: INSUPAR trial. A1 Olveira, Gabriel A1 Abuin, Jose A1 Lopez, Rafael A1 Herranz, Sandra A1 Garcia-Almeida, Jose M A1 Garcia-Malpartida, Katherine A1 Ferrer, Mercedes A1 Cancer, Emilia A1 Luengo-Perez, Luis M A1 Alvarez, Julia A1 Aragon, Carmen A1 Ocon, Maria J A1 Garcia-Manzanares, Alvaro A1 Breton, Irene A1 Serrano-Aguayo, Pilar A1 Perez-Ferre, Natalia A1 Lopez-Gomez, Juan J A1 Olivares, Josefina A1 Arraiza, Carmen A1 Tejera, Cristina A1 Martin, Jorge D A1 Garcia, Sara A1 Abad, Angel L A1 Alhambra, Maria R A1 Zugasti, Ana A1 Parra, Juan A1 Torrejon, Sara A1 Tapia, Maria J K1 Diabetes K1 Glargine insulin K1 Insulin regimen K1 Non-critically ill patient K1 TPN AB There is no established insulin regimen in T2DM patients receiving parenteral nutrition. To compare the effectiveness (metabolic control) and safety of two insulin regimens in patients with diabetes receiving TPN. Prospective, open-label, multicenter, clinical trial on adult inpatients with type 2 diabetes on a non-critical setting with indication for TPN. Patients were randomized on one of these two regimens: 100% of RI on TPN or 50% of Regular insulin added to TPN bag and 50% subcutaneous GI. Data were analyzed according to intention-to-treat principle. 81 patients were on RI and 80 on GI. No differences were observed in neither average total daily dose of insulin, programmed or correction, nor in capillary mean blood glucose during TPN infusion (165.3 ± 35.4 in RI vs 172.5 ± 43.6 mg/dL in GI; p = 0.25). Mean capillary glucose was significantly lower in the GI group within two days after TPN interruption (160.3 ± 45.1 in RI vs 141.7 ± 43.8 mg/dL in GI; p = 0.024). The percentage of capillary glucose above 180 mg/dL was similar in both groups. The rate of capillary glucose ≤70 mg/dL, the number of hypoglycemic episodes per 100 days of TPN, and the percentage of patients with non-severe hypoglycemia were significantly higher on GI group. No severe hypoglycemia was detected. No differences were observed in length of stay, infectious complications, or hospital mortality. Effectiveness of both regimens was similar. GI group achieved better metabolic control after TPN interruption but non-severe hypoglycemia rate was higher in the GI group. This trial is registered at clinicaltrials.gov as NCT02706119. PB Elsevier YR 2019 FD 2019-03-20 LK http://hdl.handle.net/10668/13775 UL http://hdl.handle.net/10668/13775 LA en NO Olveira G, Abuín J, López R, Herranz S, García-Almeida JM, García-Malpartida K, et al. Regular insulin added to total parenteral nutrition vs subcutaneous glargine in non-critically ill diabetic inpatients, a multicenter randomized clinical trial: INSUPAR trial. Clin Nutr. 2020 Feb;39(2):388-394 DS RISalud RD Jul 4, 2025