RT Journal Article
T1 Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin Resistance
A1 Boughanem, Hatim
A1 Yubero-Serrano, Elena M.
A1 López-Miranda, José
A1 Tinahones, Francisco J.
A1 Macias-Gonzalez, Manuel
K1 IGFBP2
K1 Obesity
K1 Insulin resistance
K1 Lifestyle modification
K1 Epigenetic
K1 Proteína 2 de unión a factor de crecimiento similar a la insulina
K1 Obesidad
K1 Resistencia a la insulina
K1 Estilo de vida
K1 Epigénesis genética
AB Evidence from observational and in vitro studies suggests that insulin growth-factor-binding protein type 2 (IGFBP2) is a promising protein in non-communicable diseases, such as obesity, insulin resistance, metabolic syndrome, or type 2 diabetes. Accordingly, great efforts have been carried out to explore the role of IGFBP2 in obesity state and insulin-related diseases, which it is typically found decreased. However, the physiological pathways have not been explored yet, and the relevance of IGFBP2 as an important pathway integrator of metabolic disorders is still unknown. Here, we review and discuss the molecular structure of IGFBP2 as the first element of regulating the expression of IGFBP2. We highlight an update of the association between low serum IGFBP2 and an increased risk of obesity, type 2 diabetes, metabolic syndrome, and low insulin sensitivity. We hypothesize mechanisms of IGFBP2 on the development of obesity and insulin resistance in an insulin-independent manner, which meant that could be evaluated as a therapeutic target. Finally, we cover the most interesting lifestyle modifications that regulate IGFBP2, since lifestyle factors (diet and/or physical activity) are associated with important variations in serum IGFBP2.
PB MDPI
YR 2021
FD 2021-01-24
LK http://hdl.handle.net/10668/4187
UL http://hdl.handle.net/10668/4187
LA en
NO Boughanem H, Yubero-Serrano EM, López-Miranda J, Tinahones FJ, Macias-Gonzalez M. Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin Resistance. Int J Mol Sci. 2021 Jan 24;22(3):1133
DS RISalud
RD Apr 12, 2025