RT Journal Article
T1 Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study.
A1 Gomez-Acebo, Ines
A1 Dierssen-Sotos, Trinidad
A1 Palazuelos, Camilo
A1 Fernandez-Navarro, Pablo
A1 Castaño-Vinyals, Gemma
A1 Alonso-Molero, Jessica
A1 Urtiaga, Carmen
A1 Fernandez-Villa, Tania
A1 Ardanaz, Eva
A1 Rivas-Del-Fresno, Manuel
A1 Molina-Barcelo, Ana
A1 Jimenez-Moleon, Jose-Juan
A1 Garcia-Martinez, Lidia
A1 Amiano, Pilar
A1 Rodriguez-Cundin, Paz
A1 Moreno, Víctor
A1 Perez-Gomez, Beatriz
A1 Aragones, Nuria
A1 Kogevinas, Manolis
A1 Pollan, Marina
A1 Llorca, Javier
K1 Adult
K1 Breast Neoplasms
K1 Genetic Predisposition to Disease
K1 Mendelian Randomization Analysis
K1 Pigmentation
K1 Spain
AB Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal. We examined the association between the phototype and breast and prostate cancers using a Mendelian randomization analysis. We studied 1,738 incident cases of breast cancer and another 817 cases of prostate cancer. To perform a Mendelian randomization analysis on the phototype-cancer relationship, a genetic pigmentation score was required that met the following criteria: (1) the genetic pigmentation score was associated with phototype in controls; (2) the genetic pigmentation score was not associated with confounders in the relationship between phototype and cancer, and (3) the genetic pigmentation score was associated with cancer only through its association with phototype. Once this genetic score is available, the association between genetic pigmentation score and cancer can be identified as the association between phototype and cancer. The association between the genetic pigmentation score and phototype in controls showed that a higher genetic pigmentation score was associated with fair skin, blond hair, blue eyes and the presence of freckles. Applying the Mendelian randomization analysis, we verified that there was no association between the genetic pigmentation score and cancers of the breast and prostate. Phototype is not associated with breast or prostate cancer.
PB Public Library of Science
YR 2018
FD 2018-07-20
LK http://hdl.handle.net/10668/12833
UL http://hdl.handle.net/10668/12833
LA en
NO Gómez-Acebo I, Dierssen-Sotos T, Palazuelos C, Fernández-Navarro P, Castaño-Vinyals G, Alonso-Molero J, et al. Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study. PLoS One. 2018 Aug 14;13(8):e0201750.
DS RISalud
RD Apr 10, 2025