RT Journal Article
T1 Bone marrow erythrocyte and neutrophil phagocytosis and cannibalism by neuroendocrine carcinoma.
A1 Gonzalez-Molina, Werner
A1 Avila-Polo, Rainiero
A1 Morales-Camacho, Rosario M
A1 Vargas, Maria T
A1 Bernal, Ricardo
A1 Prats-Martin, Concepcion
K1 Bone Marrow Cells
K1 Carcinoma, Neuroendocrine
K1 Female
K1 Middle Aged
K1 Phagocytosis
AB A 61-year-old non-smoking woman, who previously worked at a tobacco company for 36 years, had been diagnosed with stage IV lung adenocarcinoma 4 years earlier. After several lines of treatment, she had achieved a partial response. On this presentation, a full blood count showed pancytopenia (Hb 70 g/l, neutrophil count 0·7 × 109/l, platelet count 4 × 109/l), with a leucoerythroblastic picture. The bone marrow (BM) aspirate showed an infiltration by 86% of non-haematological neoplastic cells, of which 12% showed cell internalisation phenomena: approximately 2/3 were neutrophil (top) or erythrocyte (bottom left) haemophagocytosis and 1/3 were cellular cannibalism. Cellular cannibalism and haemophagocytosis by the same cells, and even phagocytosis of cells that had already phagocytosed other cells (bottom centre), were occasionally seen. BM histological examination showed diffuse neoplastic infiltration by medium-sized to large cells with sporadic haemophagocytosis (bottom right). Immunohistochemistry showed strong diffuse positivity for synaptophysin, and weaker staining for chromogranin A and CD56. Further images are shown in the Supplementary information. BM involvement by neuroendocrine carcinoma with a high proliferation index (Ki67: 80%) was diagnosed. Palliative care was chosen and, 3 weeks later, the patient died of septic shock and multiple organ failure.
PB Wiley-Blackwell Publishing Ltd.
YR 2018
FD 2018-07-18
LK http://hdl.handle.net/10668/12723
UL http://hdl.handle.net/10668/12723
LA en
NO González-Molina W, Ávila-Polo R, Morales-Camacho RM, Vargas MT, Bernal R, Prats-Martín C. Bone marrow erythrocyte and neutrophil phagocytosis and cannibalism by neuroendocrine carcinoma. Br J Haematol. 2018 Nov;183(4):537.
DS RISalud
RD Apr 5, 2025