TY  - JOUR
AU  - Tejada, Miguel A
AU  - Montilla-García, Angeles
AU  - Cronin, Shane J
AU  - Cikes, Domagoj
AU  - Sánchez-Fernández, Cristina
AU  - González-Cano, Rafael
AU  - Ruiz-Cantero, M Carmen
AU  - Penninger, Josef M
AU  - Vela, José M
AU  - Baeyens, José M
AU  - Cobos, Enrique J
PY  - 2017
DO  - 10.1073/pnas.1620068114
UR  - http://hdl.handle.net/10668/11415
T2  - Proceedings of the National Academy of Sciences of the United States of America
AB  - Sigma-1 antagonism potentiates the antinociceptive effects of opioid drugs, so sigma-1 receptors constitute a biological brake to opioid drug-induced analgesia. The pathophysiological role of this process is unknown. We aimed to investigate whether...
LA  - en
KW  - endogenous opioid peptides
KW  - immune cells
KW  - inflammatory pain
KW  - sigma-1 receptors
KW  - Analgesia
KW  - Analgesics, Opioid
KW  - Animals
KW  - Antigens, Ly
KW  - Carrageenan
KW  - Female
KW  - Inflammation
KW  - Macrophages
KW  - Mice
KW  - Morpholines
KW  - Naloxone
KW  - Narcotic Antagonists
KW  - Neutrophils
KW  - Oligopeptides
KW  - Pain
KW  - Piperazines
KW  - Pro-Opiomelanocortin
KW  - Pyrazoles
KW  - Quaternary Ammonium Compounds
KW  - Receptors, sigma
TI  - Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice.
TY  - research article
VL  - 114
ER  -