%0 Generic
%A Ortiz-Marquez, F.
%A Padilla-Leiva, C.
%A Cabezudo-Garcia, P.
%A Diaz-Cordobes, G.
%A Munoz-Becerra, L.
%A Mena-Vazquez, N.
%T Prospective evaluation of cognitive function in patients with juvenile idiopathic arthritis
%D 2022
%@ 0003-4967
%U http://hdl.handle.net/10668/20084
%X Background: Juvenile idiopathic arthritis (JIA) is a chronic disease requiring years of therapy with non-steroidal anti-inflammatory drugs (NSAIDs), immunosuppressant’s, cytostatics, immunobiological agents. The aforementioned drugs, namely NSAIDs and cytostatics are potentially nephrotoxic [1]. The above drugs, namely NSAIDs and cytostatics, are potentially nephrotoxic. About 8% of children with JIA have kidney damage, which develops on average 5 years after the onset of the disease. It has been established that the main risk factor for the development of kidney damage is the long-term exposure to NSAIDs and methotrexate in children with active forms of JIA [2]. Early diagnosis of kidney damage will allow timely correction in the dosage of drugs and avoid their nephrotoxic effects [3]. Objectives: To determine the effect of drug therapy in children with JIA on eGFR by using the Cystatin C-based equation and the Hoek formula based on the serum cystatin C study. Methods: 80 children with JIA participated in the study. The age of subjects was 10.4±4.41 (10.6-15.0) years. All children received methotrexate as a base drug. At the moment of examination 22 children received NSAIDs, 25 children received immunobiological preparations. Serum cystatin C content was determined by enzyme immunoassay. The Cystatin C-based equation 2012 and Hoek formulas were used to set the GFR by serum cystatin C levels.
%K Methotrexate
%K Arthritis, Juvenile
%K Immunosuppressive Agents
%K Cytostatic Agents
%K Anti-Inflammatory Agents, Non-Steroidal
%~