RT Journal Article
T1 Association of Patients' Epidemiological Characteristics and Comorbidities with Severity and Related Mortality Risk of SARS-CoV-2 Infection: Results of an Umbrella Systematic Review and Meta-Analysis.
A1 Reyna-Villasmil, Eduardo
A1 Caponcello, Maria Giulia
A1 Maldonado, Natalia
A1 Olivares, Paula
A1 Caroccia, Natascia
A1 Bonazzetti, Cecilia
A1 Tazza, Beatrice
A1 Carrara, Elena
A1 Giannella, Maddalena
A1 Tacconelli, Evelina
A1 Rodriguez-Baño, Jesus
A1 Palacios-Baena, Zaira R
K1 COVID-19
K1 SARS-CoV-2
K1 comorbidities
K1 meta-analysis
K1 mortality
K1 predictors
K1 severe disease
AB The objective of this study was to assess the association between patients’ epidemiological characteristics and comorbidities with SARS-CoV-2 infection severity and related mortality risk. An umbrella systematic review, including a meta-analysis examining the association between patients’ underlying conditions and severity (defined as need for hospitalization) and mortality of COVID-19, was performed. Studies were included if they reported pooled risk estimates of at least three underlying determinants for hospitalization, critical disease (ICU admission, mechanical ventilation), and hospital mortality in patients diagnosed with SARS-CoV-2 infection. Evidence was summarized as pooled odds ratios (pOR) for disease outcomes with 95% confidence intervals (95% CI). Sixteen systematic reviews investigating the possible associations of comorbidities with severity or death from COVID-19 disease were included. Hospitalization was associated with age > 60 years (pOR 3.50; 95% CI 2.97−4.36), smoking habit (pOR 3.50; 95% CI 2.97−4.36), and chronic pulmonary disease (pOR 2.94; 95% CI 2.14−4.04). Chronic pulmonary disease (pOR 2.82; 95% CI 1.92−4.14), cerebrovascular disease (pOR 2.74; 95% CI 1.59−4.74), and cardiovascular disease (pOR 2.44; 95% CI 1.97−3.01) were likely to be associated with increased risk of critical COVID-19. The highest risk of mortality was associated with cardiovascular disease (pOR 3.59; 95% CI 2.83−4.56), cerebrovascular disease (pOR 3.11; 95% CI 2.35−4.11), and chronic renal disease (pOR 3.02; 95% CI 2.61−3.49). In conclusion, this umbrella systematic review provides a comprehensive summary of meta-analyses examining the impact of patients’ characteristics on COVID-19 outcomes. Elderly patients and those cardiovascular, cerebrovascular, and chronic renal disease should be prioritized for pre-exposure and post-exposure prophylaxis and early treatment.
PB MDPI AG
SN 2227-9059
YR 2022
FD 2022-09-29
LK http://hdl.handle.net/10668/20846
UL http://hdl.handle.net/10668/20846
LA en
NO Reyna-Villasmil E, Caponcello MG, Maldonado N, Olivares P, Caroccia N, et al. Association of Patients' Epidemiological Characteristics and Comorbidities with Severity and Related Mortality Risk of SARS-CoV-2 Infection: Results of an Umbrella Systematic Review and Meta-Analysis. Biomedicines. 2022 Sep 29;10(10):2437.
DS RISalud
RD Apr 9, 2025