RT Journal Article
T1 Associations of persistent organic pollutants in human adipose tissue with retinoid levels and their relevance to the redox microenvironment.
A1 Galban-Velazquez, Suylen
A1 Esteban, Javier
A1 Çakmak, Gonca
A1 Artacho-Cordon, Francisco
A1 Leon, Josefa
A1 Barril, Jose
A1 Vela-Soria, Fernando
A1 Martin-Olmedo, Piedad
A1 Fernandez, Mariana F
A1 Pellin, M Cruz
A1 Arrebola, Juan P
K1 Oxidative stress
K1 Persistent organic pollutants
K1 Polychlorinated biphenyls
K1 Retinoid system
K1 Superoxide dismutase
AB Humans are exposed to a myriad of chemical substances in both occupational and environmental settings. Persistent organic pollutants (POPs) have drawn attention for their adverse effects including cancer and endocrine disruption. Herein, the objectives were 1) to describe serum and adipose tissue retinol levels, along with serum retinol binding protein 4 (RBP4) concentrations, and 2) to assess the associations of adipose tissue POP levels with these retinoid parameters, as well as their potential interaction with the previously-observed POP-related disruption of redox microenvironment. Retinol was measured in both serum and adipose tissue along with RBP4 levels in serum samples of 236 participants of the GraMo adult cohort. Associations were explored by multivariable linear regression analyses and Weighted Quantile Sum regression. Polychlorinated biphenyls (PCBs) 180, 153 and 138 were related to decreased adipose tissue retinol levels and increased serum RBP4/retinol ratio. Dicofol concentrations > limit of detection were associated with decreased retinol levels in serum and adipose tissue. Additionally, increased adipose tissue retinol levels were linked to an attenuation in previously-reported associations of adipose tissue PCB-153 with in situ superoxide dismutase activity. Our results revealed a suggestive link between retinoids, PCBs and redox microenvironment, potentially relevant for both mechanistic and public health purposes.
PB Academic Press
YR 2021
FD 2021-01-17
LK http://hdl.handle.net/10668/17044
UL http://hdl.handle.net/10668/17044
LA en
NO Galbán-Velázquez S, Esteban J, Çakmak G, Artacho-Cordón F, León J, Barril J, Vela-Soria F, et al. Associations of persistent organic pollutants in human adipose tissue with retinoid levels and their relevance to the redox microenvironment. Environ Res. 2021 Apr;195:110764.
NO This work was supported by research grants from CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Junta de Andalucía, European Regional Development Fund-FEDER (PI16/01858, PI16/01812, PI20/01568 and PI-13/02406) and Generalitat Valenciana. Dr. G Çakmak is awarded a grant by The Scientific and Technological Research Council of Turkey (TUBITAK-2219). Dr. JP Arrebola is under contract within the Ramón y Cajal Program (RYC-2016-20155, Ministerio de Economía, Industria y Competitividad, Spain).
DS RISalud
RD Apr 9, 2025