RT Journal Article
T1 Inflammatory Potential of the Diet and Incidence of Crohn's Disease and Ulcerative Colitis in the EPIC-Spain Cohort.
A1 Guevara, Marcela
A1 Salamanca-Fernandez, Elena
A1 Miqueleiz, Estrella
A1 Gavrila, Diana
A1 Amiano, Pilar
A1 Bonet, Catalina
A1 Rodriguez-Barranco, Miguel
A1 Huerta, Jose Maria
A1 Bujanda, Luis
A1 Sanchez-Perez, Maria-Jose
A1 Chirlaque, Maria Dolores
A1 Agudo, Antonio
A1 Ardanaz, Eva
A1 Castilla, Jesus
K1 Crohn’s disease
K1 inflammation
K1 inflammatory bowel disease
K1 inflammatory potential of the diet
K1 prospective cohort study
K1 ulcerative colitis
AB Diet may influence the development of inflammatory bowel disease through the modulation of inflammation. We investigated whether the inflammatory potential of the diet is associated with the risk of Crohn's disease (CD) and ulcerative colitis (UC) in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain). The study included 32,633 participants aged 29-69 years. The inflammatory potential of the diet was measured by using an inflammatory score of the diet (ISD) based on a baseline dietary history questionnaire. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). During 21 years (674,547 person-years) of follow-up, 32 and 57 participants developed CD and UC, respectively. In multivariable analysis, a one-standard deviation (SD) increment in the ISD (two-unit increase) was associated with a higher risk of CD (HR of 1.71; 95% CI: 1.05-2.80; p = 0.031). By contrast, ISD was not associated with UC (HR for one-SD increment of 0.89; 95% CI: 0.66-1.19; p = 0.436). Our results suggest that consuming a more pro-inflammatory diet may contribute to the risk of CD, supporting that a healthy diet might be beneficial in its prevention. Further, larger studies are needed to verify these findings.
PB MDPI AG
YR 2021
FD 2021-06-24
LK http://hdl.handle.net/10668/18111
UL http://hdl.handle.net/10668/18111
LA en
NO Guevara M, Salamanca-Fernández E, Miqueleiz E, Gavrila D, Amiano P, Bonet C, et al. Inflammatory Potential of the Diet and Incidence of Crohn's Disease and Ulcerative Colitis in the EPIC-Spain Cohort. Nutrients. 2021 Jun 26;13(7):2201.
DS RISalud
RD Apr 7, 2025